Circadian clock-dependent and -independent posttranscriptional regulation underlies temporal mRNA accumulation in mouse liver
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1715225115
Abstract: Significance Rhythms in gene expression propelled by the circadian clock and environmental signals are ubiquitous across cells and tissues. In particular, in mouse tissues, thousands of transcripts show oscillations with a period of 24 hours.… read more here.
Keywords: posttranscriptional regulation; regulation; circadian clock; mouse liver ... See more keywords
Thermomorphogenesis: Opportunities and challenges in posttranscriptional regulation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of experimental botany"
DOI: 10.1093/jxb/erad134
Abstract: Plants exposed to mildly elevated temperatures display morphological and developmental changes collectively termed thermomorphogenesis. This adaptative process has several undesirable consequences to food production, including yield reduction and increased vulnerability to pathogens. Understanding thermomorphogenesis is,… read more here.
Keywords: thermomorphogenesis opportunities; challenges posttranscriptional; posttranscriptional regulation; regulation ... See more keywords
Widespread posttranscriptional regulation of cotransmission.
Sign Up to like & getrecommendations! Published in 2023 at "Science advances"
DOI: 10.1126/sciadv.adg9836
Abstract: While neurotransmitter identity was once considered singular and immutable for mature neurons, it is now appreciated that one neuron can release multiple neuroactive substances (cotransmission) whose identities can even change over time. To explore the… read more here.
Keywords: widespread posttranscriptional; cholinergic; posttranscriptional regulation; regulation cotransmission ... See more keywords
MicroRNA 7 Impairs Insulin Signaling and Regulates Aβ Levels through Posttranscriptional Regulation of the Insulin Receptor Substrate 2, Insulin Receptor, Insulin-Degrading Enzyme, and Liver X Receptor Pathway
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biology"
DOI: 10.1128/mcb.00170-19
Abstract: Brain insulin resistance is a key pathological feature contributing to obesity, diabetes, and neurodegenerative disorders, including Alzheimer’s disease (AD). Besides the classic transcriptional mechanism mediated by hormones, posttranscriptional regulation has recently been shown to regulate… read more here.
Keywords: posttranscriptional regulation; insulin; receptor; insulin receptor ... See more keywords
Posttranscriptional Regulation of the Human LDL Receptor by the U2-Spliceosome
Sign Up to like & getrecommendations! Published in 2021 at "Circulation Research"
DOI: 10.1161/circresaha.120.318141
Abstract: Supplemental Digital Content is available in the text. Background: The LDLR (low-density lipoprotein receptor) in the liver is the major determinant of LDL-cholesterol levels in human plasma. The discovery of genes that regulate the activity… read more here.
Keywords: posttranscriptional regulation; ldl cholesterol; ldl; receptor ... See more keywords
PUM1 mediates the posttranscriptional regulation of human fetal hemoglobin
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2021006730
Abstract: Key Points • PUM1, an RNA-binding protein, is a novel target of EKLF that binds to fetal γ-globin mRNA and impairs its stability and translation.• Elevated HbF levels are observed upon PUM1 knockdown ex vivo… read more here.
Keywords: mediates posttranscriptional; human fetal; posttranscriptional regulation; pum1 mediates ... See more keywords
Genome-Wide Identification and Posttranscriptional Regulation Analyses Elucidate Roles of Key Argonautes and Their miRNA Triggers in Regulating Complex Yield Traits in Rapeseed
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032543
Abstract: Argonautes (AGOs) interact with microRNAs (miRNAs) to form the RNA-induced silencing complex (RISC), which can posttranscriptionally regulate the expression of targeted genes. To date, however, the AGOs and their miRNA triggers remain elusive in rapeseed… read more here.
Keywords: mirna triggers; posttranscriptional regulation; genome wide; yield traits ... See more keywords