Posttranslational modification of pyruvate kinase type M2 (PKM2): novel regulation of its biological roles to be further discovered.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of physiology and biochemistry"
DOI: 10.1007/s13105-021-00813-0
Abstract: PKM2, pyruvate kinase type M2, has been shown to play a key role in aerobic glycolysis and to regulate the malignant behaviors of cancer cells. Recently, PKM2 has been revealed to hold dual metabolic and… read more here.
Keywords: pyruvate kinase; kinase; pkm2; posttranslational modification ... See more keywords
Direct posttranslational modification of astrocytic connexin 43 proteins by the general anesthetic propofol in the cerebral cortex.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.02.142
Abstract: Propofol is widely used as a general anesthetic and is generally considered to exert its action by regulating neuronal firing via facilitation of GABAA receptors. However, accumulating evidence suggests that propofol also acts on astrocytes,… read more here.
Keywords: gap; propofol; posttranslational modification; general anesthetic ... See more keywords
Chiral Posttranslational Modification to Lysine ε-Amino Groups.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00115
Abstract: ConspectusThe sophistication of proteomic analysis has revealed that protein lysine residues are posttranslationally modified by a variety of acyl groups. Protein lysine acetylation regulates metabolism, gene expression, and microtubule formation and has been extensively studied;… read more here.
Keywords: chiral posttranslational; modification lysine; posttranslational modification; lysine ... See more keywords
Characterization of the pgf operon involved in the posttranslational modification of Streptococcus mutans surface proteins
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-23170-3
Abstract: Protein glycosylation has been described as the most abundant and complex post-translational modification occurring in nature. Recent studies have enhanced our view of how this modification occurs in bacteria highlighting the role of protein glycosylation… read more here.
Keywords: cnm; posttranslational modification; involved posttranslational; modification ... See more keywords
Signaling by hydrogen sulfide and cyanide through posttranslational modification.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of experimental botany"
DOI: 10.1093/jxb/erz225
Abstract: A new concept has arisen regarding two cysteine metabolism-related molecules, hydrogen sulfide and hydrogen cyanide, which are considered toxic but have now been established as signaling molecules. Hydrogen sulfide is produced in chloroplasts through the… read more here.
Keywords: hydrogen; posttranslational modification; cyanide; hydrogen sulfide ... See more keywords
N‐glycosylation in Archaea—New roles for an ancient posttranslational modification
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Microbiology"
DOI: 10.1111/mmi.14569
Abstract: Genome analysis points to N‐glycosylation as being an almost universal posttranslational modification in Archaea. Although such predictions have been confirmed in only a limited number of species, such studies are making it increasingly clear that… read more here.
Keywords: glycosylation archaea; posttranslational modification; glycosylation; archaea new ... See more keywords
Posttranslational modification of a histone-like protein regulates phenotypic resistance to isoniazid in mycobacteria
Sign Up to like & getrecommendations! Published in 2018 at "Science Advances"
DOI: 10.1126/sciadv.aao1478
Abstract: A bacterial histone-like protein regulates the formation of privileged, drug-tolerant subpopulations of mycobacteria. There is increasing evidence that phenotypically drug-resistant bacteria may be important determinants of antibiotic treatment failure. Using high-throughput imaging, we defined distinct… read more here.
Keywords: protein; posttranslational modification; histone like; like protein ... See more keywords
Significance of a Posttranslational Modification of the PilA Protein of Geobacter sulfurreducens for Surface Attachment, Biofilm Formation, and Growth on Insoluble Extracellular Electron Acceptors
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Bacteriology"
DOI: 10.1128/jb.00716-16
Abstract: ABSTRACT Geobacter sulfurreducens, an anaerobic metal-reducing bacterium, possesses type IV pili. These pili are intrinsic structural elements in biofilm formation and, together with a number of c-type cytochromes, are thought to serve as conductive nanowires… read more here.
Keywords: geobacter; biofilm formation; posttranslational modification; electron acceptors ... See more keywords
Posttranslational modification of the RHO of plants protein RACB by phosphorylation and cross-kingdom conserved ubiquitination
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0258924
Abstract: Small RHO-type G-proteins act as signaling hubs and master regulators of polarity in eukaryotic cells. Their activity is tightly controlled, as defective RHO signaling leads to aberrant growth and developmental defects. Two major processes regulate… read more here.
Keywords: posttranslational modification; ubiquitination; rho plants; phosphorylation ... See more keywords
Effects of the Acetyltransferase p300 on Tumour Regulation from the Novel Perspective of Posttranslational Protein Modification
Sign Up to like & getrecommendations! Published in 2023 at "Biomolecules"
DOI: 10.3390/biom13030417
Abstract: p300 acts as a transcription coactivator and an acetyltransferase that plays an important role in tumourigenesis and progression. In previous studies, it has been confirmed that p300 is an important regulator in regulating the evolution… read more here.
Keywords: acetyltransferase; protein modification; modification; tumour cell ... See more keywords
Altered Posttranslational Modification of Microtubules Contributes to Disturbed Enterocyte Morphology in Celiac Disease
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032635
Abstract: Celiac disease (CD) represents a frequent autoimmune disease triggered by the ingestion of gliadin in genetically predisposed individuals. The alteration of enterocytes and brush border membrane morphology have been repetitively demonstrated, but the underlying mechanisms… read more here.
Keywords: celiac disease; disease; morphology; posttranslational modification ... See more keywords