One-Pot Chemoenzymatic Cascade for the Enantioselective C(1)-Allylation of Tetrahydroisoquinolines
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DOI: 10.1021/jacs.2c09176
Abstract: Herein, we report a one-pot, chemoenzymatic process for the synthesis of enantioenriched C(1)-allylated tetrahydroisoquinolines. This transformation couples a monoamine oxidase (MAO-N)-catalyzed oxidation with a metal catalyzed allylboration, followed by a biocatalytic deracemization to afford allylic… read more here.
Keywords: pot chemoenzymatic; one pot; chemoenzymatic cascade; cascade enantioselective ... See more keywords