One-pot derivatization for wide-scope detection of nucleobases and deoxyribosides in natural medicinal foods with liquid chromatography-tandem mass spectrometry.
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DOI: 10.1021/acs.jafc.0c03328
Abstract: A new chemical labeling-based LC-MS/MS approach was developed for quantitative profiling of nine canonical bases and deoxynucleosides (dNs) in natural products. Using 2-bromo-1-(4-dimethylamino-phenyl)-ethaone (BrDPE) as the tagging reagent, a previously unexploited N-alkylpyrimidine derivative (Nad) was… read more here.
Keywords: natural medicinal; detection; pot derivatization; one pot ... See more keywords