A concise and focused overview upon arylglyoxal monohydrates-based one-pot multi-component synthesis of fascinating potentially biologically active pyridazines
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131742
Abstract: Abstract Pyridazine derivatives are a consequential class of heterocyclic compounds, which expose a wide range of distinguished biological activities. For example, pyridazine scaffolds are known as inhibitors of acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosine kinase (TYK),… read more here.
Keywords: arylglyoxal monohydrates; pot multi; kinase; based one ... See more keywords
Facile Synthesis of Novel Hexahydroimidazo[1,2-a]pyridine Derivatives by One-pot, Multi-component Reaction under Ambient Conditions.
Sign Up to like & getrecommendations! Published in 2020 at "ACS combinatorial science"
DOI: 10.1021/acscombsci.0c00105
Abstract: An efficient one-pot multi-component reaction for the synthesis of novel tetrasubstituted hexahydroimidazo[1,2-a]pyridines starting from readily available cinnamaldehydes, ethylenediamines and 1,3-dicarbonyl compounds catalyzed by AcOH is de-scribed. Two new cycles and four new bonds are constructed… read more here.
Keywords: synthesis novel; pot multi; multi component; ambient conditions ... See more keywords
Regioselective, one-pot, multi-component, green synthesis of substituted benzo[c]pyrazolo[2,7]naphthyridines
Sign Up to like & getrecommendations! Published in 2020 at "RSC Advances"
DOI: 10.1039/c9ra09148c
Abstract: An efficient and environmentally benign synthetic protocol has been developed for the synthesis of benzo[c]pyrazolo[2,7]naphthyridine derivatives through regioselective multi-component “on-water” reaction of isatin, malononitrile and 3-aminopyrazole. The Knoevenagel condensation of isatin with malononitrile resulted in… read more here.
Keywords: pot multi; component; multi component; benzo pyrazolo ... See more keywords
Lipase-catalyzed esterification in water enabled by nanomicelles. Applications to 1-pot multi-step sequences
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d1sc05660c
Abstract: Esterification in an aqueous micellar medium is catalyzed by a commercially available lipase in the absence of any co-factors. The presence of only 2 wt% designer surfactant, TPGS-750-M, assists in a 100% selective enzymatic process… read more here.
Keywords: pot multi; lipase catalyzed; water; esterification ... See more keywords
One-Pot, Multi-Component Synthesis of Substituted 2-(6-Phenyl-7H-[1,2,4]Triazolo[3,4-b][1,3,4]Thiadiazin-3-yl)-2,3-Dihydrophthalazine-1,4-Diones
Sign Up to like & getrecommendations! Published in 2020 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2019.1709212
Abstract: A series of 2-(6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazin-3-yl)-2,3-dihydrophthalazine-1,4-diones (4a–4o) have been synthesized via a one-pot multi-component reaction. The reaction of 4-am... read more here.
Keywords: thiadiazin dihydrophthalazine; pot multi; dihydrophthalazine diones; triazolo thiadiazin ... See more keywords
Metal-Free One-Pot Multi-Functionalization of Unsaturated Compounds with Interelement Compounds by Radical Process
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28020787
Abstract: In recent years, the importance of “environmentally friendly manufacturing” has been increasing toward the establishment of a resource-recycling society. In organic synthesis, as well, it is becoming increasingly important to develop new synthetic strategies with… read more here.
Keywords: free one; metal free; functional groups; multi functionalization ... See more keywords