POT1 mutations cause differential effects on telomere length leading to opposing disease phenotypes.
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DOI: 10.1002/jcp.31034
Abstract: The protection of telomere protein (POT1) is a telomere-binding protein and is an essential component of the six-membered shelterin complex, which is associated with the telomeres. POT1 directly binds to the 3' single-stranded telomeric overhang and prevents the… read more here.
Keywords: disease phenotypes; telomere length; mutations cause; pot1 mutations ... See more keywords
The prevalence and characterisation of TRAF3 and POT1 mutations in canine B-cell lymphoma.
Sign Up to like & getrecommendations! Published in 2020 at "Veterinary journal"
DOI: 10.1016/j.tvjl.2020.105575
Abstract: The genetic and mutational basis of canine lymphoma remains poorly understood. Several genes, including TRAF3 and POT1, are mutated in canine B-cell lymphoma (cBCL), and are likely involved in the pathogenesis of this disease. The… read more here.
Keywords: cell lymphoma; pot1 mutations; traf3; traf3 pot1 ... See more keywords
POT1 mutations are frequent and associated with Ki-67 index in canine diffuse large B-cell lymphoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Veterinary Science"
DOI: 10.3389/fvets.2022.968807
Abstract: Diffuse large B-cell lymphoma (DLBCL) represents one of the most frequent and deadliest neoplasia in dogs worldwide and is characterized by a remarkable degree of clinical heterogeneity, with poor chances to anticipate the outcome. Even… read more here.
Keywords: pot1; cell lymphoma; large cell; diffuse large ... See more keywords