Germline POT1 Variants Can Predispose to a Variety of Hematologic Neoplasms
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DOI: 10.1182/blood-2020-134160
Abstract: Germline mutations in the shelterin component protection of telomeres 1 (POT1) were recently found to be associated with familial chronic lymphocytic leukemia (CLL), melanoma, glioma, and several other familial cancer syndromes. The role of POT1… read more here.
Keywords: hematologic; pot1 variants; malignancy; germline pot1 ... See more keywords
Germline POT1 Variants: A Critical Perspective on POT1 Tumor Predisposition Syndrome
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DOI: 10.3390/genes15010104
Abstract: The Protection of Telomere 1 (POT1) gene was identified as a melanoma predisposition candidate nearly 10 years ago. Thereafter, various cancers have been proposed as associated with germline POT1 variants in the context of the… read more here.
Keywords: germline pot1; pot1; pot1 variants; critical perspective ... See more keywords