Expression and production of recombinant scorpine as a potassium channel blocker protein in Escherichia coli
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Applied Biochemistry"
DOI: 10.1002/bab.1704
Abstract: Scorpine is a cationic protein from the venom of Pandinus imperator, belonging to potassium channel blocker family, which has been shown to have antibacterial, antiviral, and antiplasmodia activities. In the present study, a pET‐44a vector… read more here.
Keywords: protein; production; potassium channel; recombinant scorpine ... See more keywords
The potassium channel KCa3.1 promotes cell proliferation by activating SKP2 and metastasis through the EMT pathway in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Cancer"
DOI: 10.1002/ijc.32121
Abstract: The intermediate conductance calcium‐activated potassium channel (KCa3.1) plays an important role in maintaining intracellular calcium homeostasis and is involved in the tumorigenesis of many human cancers. However, it is unknown whether KCa3.1 plays a role… read more here.
Keywords: hepatocellular carcinoma; hcc; cell proliferation; potassium channel ... See more keywords
Identification and Pharmacological Characterization of the Voltage-gated Potassium Channel Shab in Diamondback moth, Plutella xylostella.
Sign Up to like & getrecommendations! Published in 2022 at "Pest management science"
DOI: 10.1002/ps.7300
Abstract: BACKGROUND Voltage-gated potassium channel Kv2 is the primarily delayed rectifier in insect nerves and muscles involved in several crucial biological processes, including action potential regulation, photoreceptor performance, and larval locomotor. It is a potential molecular… read more here.
Keywords: gated potassium; voltage gated; plutella xylostella; potassium channel ... See more keywords
Utilising Automated Electrophysiological Platforms in Epilepsy Research.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0818-0_7
Abstract: Genetic mutations have long been implicated in epilepsy, particularly in genes that encode ion channels and neurotransmitter receptors. Among some of those identified are voltage-gated sodium, potassium and calcium channels, and ligand-gated gamma-aminobutyric acid (GABA),… read more here.
Keywords: epilepsy; potassium; potassium channel; channel ... See more keywords
Examining the role of phosphorylation on interactions between the cardiac potassium channel alpha-subunits hERG and KvLQT1
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.619
Abstract: KvLQT1 and hERG are the voltage-gated K+ channel α-subunits of the channels which carry the cardiac repolarizing currents IKs and IKr, respectively. These currents function in vivo with some redundancy to maintain appropriate action potential… read more here.
Keywords: herg kvlqt1; potassium channel; kvlqt1; phosphorylation ... See more keywords
Mechanism of Mechanosensitive Gating of the TREK-2 Potassium Channel.
Sign Up to like & getrecommendations! Published in 2018 at "Biophysical journal"
DOI: 10.1016/j.bpj.2018.01.030
Abstract: The mechanism of mechanosensitive gating of ion channels underlies many physiological processes, including the sensations of touch, hearing, and pain perception. TREK-2 is the best-studied mechanosensitive member of the two-pore domain potassium channel family. Apart… read more here.
Keywords: potassium channel; mechanosensitive gating; conductance; channel ... See more keywords
Electrostatic Tuning of a Potassium Channel in Electric Fish
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.05.012
Abstract: Molecular variation contributes to the evolution of adaptive phenotypes, though it is often difficult to understand precisely how. The adaptively significant electric organ discharge behavior of weakly electric fish is the direct result of biophysical… read more here.
Keywords: electrostatic tuning; potassium channel; tuning potassium; electric organ ... See more keywords
The potassium channel Kv4.2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice
Sign Up to like & getrecommendations! Published in 2020 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2020.113437
Abstract: The voltage-gated potassium channel Kv4.2 is a critical regulator of dendritic excitability in the hippocampus and is crucial for dendritic signal integration. Kv4.2 mRNA and protein expression as well as function are reduced in several… read more here.
Keywords: dendritic spine; potassium channel; morphology; kv4 ... See more keywords
Changes in phagocytosis and potassium channel activity in microglia of 5xFAD mice indicate alterations in purinergic signaling in a mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2017 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2017.05.027
Abstract: As the immunocompetent cells of the central nervous system, microglia accumulate at amyloid beta plaques in Alzheimer's disease (AD) and acquire a morphological phenotype of activated microglia. Recent functional studies, however, indicate that in mouse… read more here.
Keywords: alzheimer disease; potassium channel; channel activity; activity ... See more keywords
Targeting the TREK-1 potassium channel via riluzole to eliminate the neuropathic and depressive-like effects of oxaliplatin
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.07.026
Abstract: Abstract: Neurotoxicity remains the most common adverse effect of oxaliplatin, limiting its clinical use. In the present study, we developed a mouse model of chronic oxaliplatin‐induced neuropathy, which mimics both sensory and motor deficits observed… read more here.
Keywords: potassium channel; trek potassium; effect; channel ... See more keywords
Pharmacological characterization of human beta-defensins 3 and 4 on potassium channels: Evidence of diversity in beta-defensin-potassium channel interactions
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2018.08.005
Abstract: &NA; Recent reports have identified defensins as a new type of potassium channel inhibitors; differential binding mechanisms of human &bgr;‐defensins hBD1 and hBD2 point to complex interactions between human &bgr;‐defensins and potassium channels. We investigated… read more here.
Keywords: potassium channels; potassium channel; beta; channel ... See more keywords