Phylogenetic and developmental analyses indicate complex functions of calcium‐activated potassium channels in zebrafish embryonic development
Sign Up to like & getrecommendations! Published in 2021 at "Developmental Dynamics"
DOI: 10.1002/dvdy.329
Abstract: Calcium‐activated potassium channels (KCa) are a specific type of potassium channel activated by intracellular calcium concentration changes. This group of potassium channels plays fundamental roles ranging from regulating neuronal excitability to immune cell activation. Many… read more here.
Keywords: potassium channels; activated potassium; potassium; calcium activated ... See more keywords
The role of Ca2+‐dependent K+‐ channels at the rat corticostriatal synapses revealed by paired pulse stimulation
Sign Up to like & getrecommendations! Published in 2018 at "Synapse"
DOI: 10.1002/syn.22017
Abstract: Potassium channels play an important role in modulating synaptic activity both at presynaptic and postsynaptic levels. We have shown before that presynaptically located KV and KIR channels modulate the strength of corticostriatal synapses in rat… read more here.
Keywords: potassium channels; corticostriatal synapses; role ca2; paired pulse ... See more keywords
Chronic Alcohol, Intrinsic Excitability, and Potassium Channels: Neuroadaptations and Drinking Behavior.
Sign Up to like & getrecommendations! Published in 2018 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2017_90
Abstract: Neural mechanisms underlying alcohol use disorder remain elusive, and this lack of understanding has slowed the development of efficacious treatment strategies for reducing relapse rates and prolonging abstinence. While synaptic adaptations produced by chronic alcohol… read more here.
Keywords: potassium channels; hyperpolarization; intrinsic excitability; chronic alcohol ... See more keywords
High-Resolution Structures of K+ Channels.
Sign Up to like & getrecommendations! Published in 2021 at "Handbook of experimental pharmacology"
DOI: 10.1007/164_2021_454
Abstract: Potassium channels are present in every living cell and essential to setting up a stable, non-zero transmembrane electrostatic potential which manifests the off-equilibrium livelihood of the cell. They are involved in other cellular activities and… read more here.
Keywords: structures channels; potassium channels; high resolution; channels high ... See more keywords
Psychotropic Effects of a New Pyrazolo[C]Pyridine Derivate GIZh-72 are Related to Functional Activity of Atp-Sensitive Potassium Channels
Sign Up to like & getrecommendations! Published in 2020 at "Bulletin of Experimental Biology and Medicine"
DOI: 10.1007/s10517-020-04729-5
Abstract: We studied the influence of intraperitoneal injection of ATP-sensitive potassium channels inhibitor glibenclamide in doses of 0.01, 0.1, 1, and 10 mg/kg on the effects of a new pyrazolo[C]pyridine derivative GIZh-72 (4,6-dimethyl-2-(4-chlorphenyl)-2,3-dihydro-1Hpyrazolo[ 4,3-C]pyridine-3-on, chloral hydrate;… read more here.
Keywords: potassium channels; sensitive potassium; effects new; atp sensitive ... See more keywords
BK Potassium Channels Suppress Cavα2δ Subunit Function to Reduce Inflammatory and Neuropathic Pain.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.01.073
Abstract: Cavα2δ subunits contribute to the cell-surface expression of Cav2 calcium channels. Upregulation of Cavα2δ-1 in dorsal root ganglion neurons occurs after nerve injury and results in an increased synaptic abundance of Cav2.2 channels in the… read more here.
Keywords: potassium channels; neuropathic pain; subunit; cav subunit ... See more keywords
Pharmacological characterization of human beta-defensins 3 and 4 on potassium channels: Evidence of diversity in beta-defensin-potassium channel interactions
Sign Up to like & getrecommendations! Published in 2018 at "Peptides"
DOI: 10.1016/j.peptides.2018.08.005
Abstract: &NA; Recent reports have identified defensins as a new type of potassium channel inhibitors; differential binding mechanisms of human &bgr;‐defensins hBD1 and hBD2 point to complex interactions between human &bgr;‐defensins and potassium channels. We investigated… read more here.
Keywords: potassium channels; potassium channel; beta; channel ... See more keywords
Ion Conduction Mechanisms in Potassium Channels Revealed by Permeation Cycles
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Chemical Theory and Computation"
DOI: 10.1021/acs.jctc.3c00061
Abstract: Potassium channels are responsible for the selective yet efficient permeation of potassium ions across cell membranes. Despite many available high-resolution structures of potassium channels, those conformations inform only on static information on the ion permeation… read more here.
Keywords: potassium channels; permeation cycles; conduction mechanisms; permeation ... See more keywords
Molecular tuning of electroreception in sharks and skates
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/s41586-018-0160-9
Abstract: Ancient cartilaginous vertebrates, such as sharks, skates and rays, possess specialized electrosensory organs that detect weak electric fields and relay this information to the central nervous system1–4. Sharks exploit this sensory modality for predation, whereas… read more here.
Keywords: voltage; potassium channels; molecular tuning; electrosensory cells ... See more keywords
SLO potassium channels antagonize premature decision making in C. elegans
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0124-5
Abstract: Animals must modify their behavior with appropriate timing to respond to environmental changes. Yet, the molecular and neural mechanisms regulating the timing of behavioral transition remain largely unknown. By performing forward genetics to reveal mechanisms… read more here.
Keywords: potassium channels; premature decision; antagonize premature; channels antagonize ... See more keywords
Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40825
Abstract: Mammalian Eag1 (Kv10.1) potassium (K+) channels are widely expressed in the brain. Several mutations in the gene encoding human Eag1 K+ channel have been associated with congenital neurodevelopmental anomalies. Currently very little is known about… read more here.
Keywords: potassium channels; mediates proteasomal; reag1; lysosomal degradations ... See more keywords