ADAM23 is a negative regulator of Kv1.1/Kv1.4 potassium currents
Sign Up to like & getrecommendations! Published in 2019 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2019.04.012
Abstract: Background ADAM22 and ADAM23 are transmembrane proteins that bind the secreted synaptic protein LGI1 and associate with Kv1.1/Kv1.4 potassium channels. However, the roles of these proteins in regulated voltage-gated potassium currents are poorly understood. Methods… read more here.
Keywords: kv1; kv1 kv1; kv1 currents; lgi1 ... See more keywords
Modulation of potassium conductances optimizes fidelity of auditory information.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2216440120
Abstract: Potassium channels in auditory neurons are rapidly modified by changes in the auditory environment. In response to elevated auditory stimulation, short-term mechanisms such as protein phosphorylation and longer-term mechanisms such as accelerated channel synthesis increase… read more here.
Keywords: information; potassium; auditory; potassium currents ... See more keywords
Clemizole hydrochloride blocks cardiac potassium currents stably expressed in HEK 293 cells
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Pharmacology"
DOI: 10.1111/bph.13679
Abstract: Clemizole, a histamine H1 receptor antagonist has a potential therapeutic effect on hepatitis C infection and also potently inhibits TRPC5 ion channels. The aim of the present study was to investigate whether clemizole blocks cardiac… read more here.
Keywords: cardiac potassium; currents stably; hydrochloride blocks; clemizole hydrochloride ... See more keywords
Aluminum alters excitability by inhibiting calcium, sodium, and potassium currents in bovine chromaffin cells
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15784
Abstract: Aluminum (Al3+) has long been related to neurotoxicity and neurological diseases. This study aims to describe the specific actions of this metal on cellular excitability and neurotransmitter release in primary culture of bovine chromaffin cells.… read more here.
Keywords: calcium; aluminum; potassium currents; sodium ... See more keywords