The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome‐Induced Inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.04.032
Abstract: Summary Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP‐induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive. Here we identified the two‐pore… read more here.
Keywords: nlrp3 inflammasome; channel; twik2; potassium efflux ... See more keywords
The Critical Role of Potassium Efflux and Nek7 in Pasteurella multocida-Induced NLRP3 Inflammasome Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.849482
Abstract: Pasteurella multocida is a zoonotic pathogen causing respiratory infection in different animal species such as cattle, sheep, pigs, chickens and humans. Inflammasome is a complex assembled by multiple proteins in the cytoplasm and plays an… read more here.
Keywords: potassium efflux; activation; nlrp3 inflammasome; pasteurella multocida ... See more keywords
The Potassium Efflux System Kef: Bacterial Protection against Toxic Electrophilic Compounds
Sign Up to like & getrecommendations! Published in 2023 at "Membranes"
DOI: 10.3390/membranes13050465
Abstract: Kef couples the potassium efflux with proton influx in gram-negative bacteria. The resulting acidification of the cytosol efficiently prevents the killing of the bacteria by reactive electrophilic compounds. While other degradation pathways for electrophiles exist,… read more here.
Keywords: system; electrophilic compounds; domain; efflux system ... See more keywords