High-throughput on-chip human mesenchymal stromal cell potency prediction.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101995
Abstract: Human mesenchymal stromal cells (hMSCs) are a promising source for regenerative cell therapy. However, hMSC clinical use has been stymied by product variability across hMSC donors and manufacturing practices resulting in inconsistent clinical outcomes. The… read more here.
Keywords: mesenchymal stromal; human mesenchymal; potency; high throughput ... See more keywords
Optimizing Lipid Nanoparticles for Delivery in Primates.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202211420
Abstract: Lipid nanoparticles (LNPs) are clinically proven to successfully deliver both small interfering RNA (siRNA) therapeutics and larger mRNA payloads for prophylactic vaccine applications. Non-human primates (NHPs) are generally considered to be the most predictive of… read more here.
Keywords: nanoparticles delivery; potency; optimizing lipid; delivery primates ... See more keywords
Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced materials"
DOI: 10.1002/adma.202303370
Abstract: The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic lipid component. LNP mRNA systems composed of optimized ionizable lipids often display distinctive mRNA rich "bleb" structures. Here we… read more here.
Keywords: improved transfection; transfection potency; potency; lipid nanoparticle ... See more keywords
New Insights into Tolytoxin Effect in Human Cancer Cells: Apoptosis Induction and the Relevance of Hydroxyl Substitution of Its Macrolide Cycle on Compound Potency
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202100489
Abstract: Scytophycins, including tolytoxin, represent a class of actin disrupting macrolides with strong antiproliferative effects on human cells. Despite intense research, little attention has been paid to scytophycin‐induced cell death or the structural features affecting its… read more here.
Keywords: hydroxyl substitution; potency; effect; new insights ... See more keywords
Optimization of Substrate‐Analogue Furin Inhibitors
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DOI: 10.1002/cmdc.201700596
Abstract: The proprotein convertase furin is a potential target for drug design, especially for the inhibition of furin‐dependent virus replication. All effective synthetic furin inhibitors identified thus far are multibasic compounds; the highest potency was found… read more here.
Keywords: substrate analogue; optimization substrate; potency; furin inhibitors ... See more keywords
Comparing BMD‐derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay
Sign Up to like & getrecommendations! Published in 2017 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22137
Abstract: There is growing interest in quantitative analysis of in vivo genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Currently, multiple transgenic… read more here.
Keywords: dose response; potency; bmd; transgenic rodent ... See more keywords
Quantitative differentiation of whole smoke solution‐induced mutagenicity in the mouse lymphoma assay
Sign Up to like & getrecommendations! Published in 2018 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22151
Abstract: In vitro genotoxicity dose–response data have been investigated for their utility in modeling and assessing potential differences in mutagenic responses between machine‐generated whole smoke solutions (WSSs) from combusted cigarette tobacco products. Our previous study observed… read more here.
Keywords: whole smoke; potency; mouse lymphoma; lymphoma assay ... See more keywords
The in vitro genotoxicity potency of mixtures of pyrrolizidine alkaloids can be explained by dose addition of the individual mixture components
Sign Up to like & getrecommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22512
Abstract: Plant‐based 1,2‐unsaturated Pyrrolizidine Alkaloids (PAs) are responsible for liver genotoxicity/carcinogenicity following metabolic activation, making them a relevant concern for safety assessment. Due to 21st century toxicology approaches, risk of PAs can be better discerned though… read more here.
Keywords: potency; vitro genotoxicity; genotoxic potency; genotoxicity potency ... See more keywords
Quantitative interpretation of ToxTracker dose–response data for potency comparisons and mode‐of‐action determination
Sign Up to like & getrecommendations! Published in 2023 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22525
Abstract: ToxTracker is an in vitro mammalian stem cell‐based reporter assay that detects activation of specific cellular signaling pathways (DNA damage, oxidative stress, and/or protein damage) upon chemical exposure using flow cytometry. Here we used quantitative… read more here.
Keywords: stress; potency; response data; dose response ... See more keywords
Predicting Early Life Stage Mortality in Birds and Fishes from Exposure to Low Potency Agonists of the Aryl Hydrocarbon Receptor: A Cross-species Quantitative Adverse Outcome Pathway Approach.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.4816
Abstract: Dioxin-like compounds (DLCs) cause early life stage mortality of vertebrates through activation of the aryl hydrocarbon receptor (AHR). A prior study developed a cross-species quantitative adverse outcome pathway (qAOP) which can predict full dose-response curves… read more here.
Keywords: potency agonists; potency; early life; mortality ... See more keywords
Impact of organism allocations on potency estimates from C. dubia reproduction tests.
Sign Up to like & getrecommendations! Published in 2023 at "Environmental toxicology and chemistry"
DOI: 10.1002/etc.5625
Abstract: In aquatic toxicology experiments, organisms are randomly assigned to an exposure group that receives a particular concentration level of a toxicant (including a control group with no exposure), and their survival, growth, or reproduction outcomes… read more here.
Keywords: toxicology; impact organism; potency; concentration ... See more keywords