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   Articles with "potency" as a keyword



High-throughput on-chip human mesenchymal stromal cell potency prediction.

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recommendations! Published in 2021 at "Advanced healthcare materials"

DOI: 10.1002/adhm.202101995

Abstract: Human mesenchymal stromal cells (hMSCs) are a promising source for regenerative cell therapy. However, hMSC clinical use has been stymied by product variability across hMSC donors and manufacturing practices resulting in inconsistent clinical outcomes. The… read more here.

Keywords: mesenchymal stromal; human mesenchymal; potency; high throughput ... See more keywords

Optimizing Lipid Nanoparticles for Delivery in Primates.

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recommendations! Published in 2023 at "Advanced materials"

DOI: 10.1002/adma.202211420

Abstract: Lipid nanoparticles (LNPs) are clinically proven to successfully deliver both small interfering RNA (siRNA) therapeutics and larger mRNA payloads for prophylactic vaccine applications. Non-human primates (NHPs) are generally considered to be the most predictive of… read more here.

Keywords: nanoparticles delivery; potency; optimizing lipid; delivery primates ... See more keywords

Induction of Bleb Structures in Lipid Nanoparticle Formulations of mRNA Leads to Improved Transfection Potency.

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recommendations! Published in 2023 at "Advanced materials"

DOI: 10.1002/adma.202303370

Abstract: The transfection potency of lipid nanoparticle (LNP) mRNA systems is critically dependent on the ionizable cationic lipid component. LNP mRNA systems composed of optimized ionizable lipids often display distinctive mRNA rich "bleb" structures. Here we… read more here.

Keywords: improved transfection; transfection potency; potency; lipid nanoparticle ... See more keywords

New Insights into Tolytoxin Effect in Human Cancer Cells: Apoptosis Induction and the Relevance of Hydroxyl Substitution of Its Macrolide Cycle on Compound Potency

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recommendations! Published in 2021 at "ChemBioChem"

DOI: 10.1002/cbic.202100489

Abstract: Scytophycins, including tolytoxin, represent a class of actin disrupting macrolides with strong antiproliferative effects on human cells. Despite intense research, little attention has been paid to scytophycin‐induced cell death or the structural features affecting its… read more here.

Keywords: hydroxyl substitution; potency; effect; new insights ... See more keywords

Evaluation of Potency and Specificity of Cryptophycin‐Loaded Antibody‐Drug Conjugates

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recommendations! Published in 2024 at "ChemBioChem"

DOI: 10.1002/cbic.202400738

Abstract: An enhanced variant of the antimitotic toxin cryptophycin was conjugated to the anti‐Her2 monoclonal antibody (mAb) Trastuzumab upon Michael addition. Either antibodies with freed hinge‐region cysteines or THIOMAB formats with engineered cysteines in the mAbs… read more here.

Keywords: cryptophycin; potency; cell; antibody drug ... See more keywords

Optimization of Substrate‐Analogue Furin Inhibitors

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recommendations! Published in 2017 at "ChemMedChem"

DOI: 10.1002/cmdc.201700596

Abstract: The proprotein convertase furin is a potential target for drug design, especially for the inhibition of furin‐dependent virus replication. All effective synthetic furin inhibitors identified thus far are multibasic compounds; the highest potency was found… read more here.

Keywords: substrate analogue; optimization substrate; potency; furin inhibitors ... See more keywords

Comparing BMD‐derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay

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recommendations! Published in 2017 at "Environmental and Molecular Mutagenesis"

DOI: 10.1002/em.22137

Abstract: There is growing interest in quantitative analysis of in vivo genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Currently, multiple transgenic… read more here.

Keywords: dose response; potency; bmd; transgenic rodent ... See more keywords

Quantitative differentiation of whole smoke solution‐induced mutagenicity in the mouse lymphoma assay

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recommendations! Published in 2018 at "Environmental and Molecular Mutagenesis"

DOI: 10.1002/em.22151

Abstract: In vitro genotoxicity dose–response data have been investigated for their utility in modeling and assessing potential differences in mutagenic responses between machine‐generated whole smoke solutions (WSSs) from combusted cigarette tobacco products. Our previous study observed… read more here.

Keywords: whole smoke; potency; mouse lymphoma; lymphoma assay ... See more keywords

The in vitro genotoxicity potency of mixtures of pyrrolizidine alkaloids can be explained by dose addition of the individual mixture components

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recommendations! Published in 2022 at "Environmental and Molecular Mutagenesis"

DOI: 10.1002/em.22512

Abstract: Plant‐based 1,2‐unsaturated Pyrrolizidine Alkaloids (PAs) are responsible for liver genotoxicity/carcinogenicity following metabolic activation, making them a relevant concern for safety assessment. Due to 21st century toxicology approaches, risk of PAs can be better discerned though… read more here.

Keywords: potency; vitro genotoxicity; genotoxic potency; genotoxicity potency ... See more keywords

Quantitative interpretation of ToxTracker dose–response data for potency comparisons and mode‐of‐action determination

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recommendations! Published in 2023 at "Environmental and Molecular Mutagenesis"

DOI: 10.1002/em.22525

Abstract: ToxTracker is an in vitro mammalian stem cell‐based reporter assay that detects activation of specific cellular signaling pathways (DNA damage, oxidative stress, and/or protein damage) upon chemical exposure using flow cytometry. Here we used quantitative… read more here.

Keywords: stress; potency; response data; dose response ... See more keywords

Using N‐Nitrosodiethanolamine (NDELA) and N‐Nitrosopiperidine (NPIP) Transgenic Rodent Gene Mutation Data and Quantum Mechanical Modeling to Derive Potency‐Based Acceptable Intakes for NDSRIs Lacking Robust Carcinogenicity Data

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recommendations! Published in 2025 at "Environmental and Molecular Mutagenesis"

DOI: 10.1002/em.70012

Abstract: Acceptable intake (AI) limits for nitrosamine drug substance related impurities (NDSRIs) that lack carcinogenicity data could be estimated from mutagenic potency relative to anchor nitrosamines with carcinogenicity data. This approach integrates points of departure (PoDs)… read more here.

Keywords: npip; carcinogenicity data; gene mutation; potency ... See more keywords