Impact of stereopure chimeric backbone chemistries on the potency and durability of gene silencing by RNA interference
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DOI: 10.1093/nar/gkad268
Abstract: Abstract Herein, we report the systematic investigation of stereopure phosphorothioate (PS) and phosphoryl guanidine (PN) linkages on siRNA-mediated silencing. The incorporation of appropriately positioned and configured stereopure PS and PN linkages to N-acetylgalactosamine (GalNAc)-conjugated siRNAs… read more here.
Keywords: potency durability; stereopure; impact stereopure; rna interference ... See more keywords