Improved Synthesis of Yt-14, A Potent Antibiotic to Multidrug-Resistant Strains
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DOI: 10.3184/174751918x15314830456124
Abstract: A new practical synthetic approach produced clinical drug candidate YT-14, improving the overall yield from 1.3% to 13.8%. Compared with the previous route, the new route is two steps shorter and all of the steps… read more here.
Keywords: improved synthesis; potent antibiotic; antibiotic multidrug; synthesis potent ... See more keywords
Potent Antibiotic Lemonomycin: A Glimpse of Its Discovery, Origin, and Chemical Synthesis
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DOI: 10.3390/molecules27134324
Abstract: Lemonomycin (1) was first isolated from the fermentation broth of Streptomyces candidus in 1964. The complete chemical structure was not elucidated until 2000 with extensive spectroscopic analysis. Lemonomycin is currently known as the only glycosylated… read more here.
Keywords: chemical synthesis; antibiotic lemonomycin; potent antibiotic; synthesis ... See more keywords