Benzimidazole‐oxindole hybrids: A novel class of selective dual CDK2 and GSK‐3β inhibitors of potent anticancer activity
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202300721
Abstract: A new series of benzimidazole‐oxindole hybrids 8a–x was discovered as dual cyclin‐dependent kinase (CDK2) and glycogen synthase kinase‐3‐beta (GSK‐3β) inhibitors with potent anticancer activity. The synthesized hits displayed potent anticancer activity against national cancer institute… read more here.
Keywords: cdk2; cdk2 gsk; benzimidazole oxindole; potent anticancer ... See more keywords
Synthesis of dual-action parthenolide prodrugs as potent anticancer agents.
Sign Up to like & getrecommendations! Published in 2017 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2017.01.020
Abstract: Cancer stem cells are responsible for the failure of a large number of cancer treatments and the re-emergence of cancer in patients. Parthenolide is a potent anticancer sesquiterpene lactone that is also able to kill… read more here.
Keywords: cancer; synthesis dual; parthenolide prodrugs; potent anticancer ... See more keywords
Synthesis and evaluation of N-heteroaromatic ring-based analogs of piperlongumine as potent anticancer agents.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.046
Abstract: Piperlongumine (PL) selectively targets a wide spectrum of cancer cells and induces their death by triggering various pathways, including apoptosis, necrosis and autophagy. However, the poor solubility is a serious concern for intensive study and… read more here.
Keywords: heteroaromatic ring; based analogs; potent anticancer; ring ... See more keywords
Design, synthesis and anticancer activity of fluorocyclopentenyl-purines and - pyrimidines.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.06.003
Abstract: Based on the potent anticancer activity of 6'-fluorocyclopentenyl-cytosine 2b in phase IIa clinical trials for the treatment of gemcitabine-resistant pancreatic cancer, we carried out a systematic structure-activity relationship study of 6'-fluorocyclopentenyl-pyrimidines 3a-i and -purines 3j-o… read more here.
Keywords: group; activity fluorocyclopentenyl; anticancer activity; potent anticancer ... See more keywords
Drug repurposing and relabeling for cancer therapy: Emerging benzimidazole antihelminthics with potent anticancer effects.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118189
Abstract: Origin of drug and radio-refractory clones, cancer stem-like cells, and rapid angiogenesis and metastasis are among the primary concerns that limit the efficacy of anticancer treatments, emphasizing the urgency of developing new therapeutics. Factors like… read more here.
Keywords: benzimidazole antihelminthics; drug; potent anticancer; cancer ... See more keywords
Ferrocene-functionalized anilines as potent anticancer and antidiabetic agents: Synthesis, spectroscopic elucidation, and DFT calculations
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.131632
Abstract: Abstract Ferrocene derivatives have attracted significant interest as potent biological agents and novel drug candidates. Hence, the present research work was focused on the synthesis and characterization of ferrocene-integrated anilines (FB1-FB4) through different spectroscopic techniques… read more here.
Keywords: ferrocene; ferrocene functionalized; functionalized anilines; spectroscopic ... See more keywords
A non-cytotoxic dendrimer with innate and potent anticancer and anti-metastatic activities
Sign Up to like & getrecommendations! Published in 2017 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-017-0130-9
Abstract: The structural perfection and multivalency of dendrimers have made them useful for biodelivery and bioactivity via peripheral functionalization and the modulation of core-forming structures and dendrimer generations. Yet only few dendrimers have shown inherent therapeutic… read more here.
Keywords: dendrimer; anticancer activity; potent anticancer; non cytotoxic ... See more keywords
New Self-assembled Supramolecular Bowls as Potent Anticancer Agents for Human Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-018-36755-9
Abstract: We report herein on the design, synthesis and biological activity of Ru-based self-assembled supramolecular bowls as a potent anticancer therapeutic in human hepatocellular cancer. The potent complex induces production of reactive oxygen species (ROS) by… read more here.
Keywords: supramolecular bowls; self assembled; potent anticancer; assembled supramolecular ... See more keywords
Dual-functional cyclometalated iridium imine NHC complexes: highly potent anticancer and antimetastatic agents
Sign Up to like & getrecommendations! Published in 2018 at "Inorganic chemistry frontiers"
DOI: 10.1039/c8qi00920a
Abstract: A new class of cyclometalated iridium(III) complexes with imine-N-heterocyclic carbenes (NHC) as ligands were synthesized and fully characterized. One crystal structure is reported. All the six complexes exhibited highly potent anticancer activity against A549 cells,… read more here.
Keywords: highly potent; functional cyclometalated; dual functional; potent anticancer ... See more keywords
Discovery of Potent Anticancer Tricarboxamide Analogs Linked to 1,2,3-Triazole, Promoting EGFR and VEGFR Downregulation
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DOI: 10.1039/d5nj01143d
Abstract: This study reports the click synthesis of new sets of tricarboxamide and/or tricarboxylate-based 1,2,3-triazoles tethering various lipophilic and hypophilic side chains under optimized Cu(I)-Catalyzed Azide Alkyne Cycloaddition reaction (CuAAC). A... read more here.
Keywords: linked triazole; discovery potent; anticancer tricarboxamide; analogs linked ... See more keywords
Design of a potent anticancer lead inspired by natural products from traditional Indian medicine
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1664326
Abstract: Abstract Among the plant constituents of Clerodendrum colebrookianum Walp., acteoside, martinoside, and osmanthuside β6 interact with ROCK, a drug target for cancer. In this study, aglycone fragments of these plant constituents (caffeic acid, ferulic acid,… read more here.
Keywords: medicine; design potent; potent anticancer; anticancer lead ... See more keywords