Design, Synthesis, Structure‐Activity Relationship and Docking Studies of Novel Functionalized Arylvinyl‐1,2,4‐Trioxanes as Potent Antiplasmodial as well as Anticancer Agents
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DOI: 10.1002/cmdc.202000045
Abstract: A novel series of synthetic functionalized arylvinyl‐1,2,4‐trioxanes (8 a–p) has been prepared and assessed for their in vitro antiplasmodial activity against the chloroquine‐resistant Pf INDO strain of Plasmodium falciparum by using a SYBR green‐I fluorescence assay. Compounds… read more here.
Keywords: functionalized arylvinyl; docking studies; arylvinyl trioxanes; ic50 ... See more keywords
Identification of novel quinazoline derivatives as potent antiplasmodial agents.
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DOI: 10.1016/j.ejmech.2018.10.041
Abstract: Despite the recent reductions in the global burden of malaria, this disease remains a devastating cause of death in tropical and subtropical regions. As there is no broadly effective vaccine for malaria, prevention and treatment… read more here.
Keywords: derivatives potent; antiplasmodial agents; quinazoline derivatives; potent antiplasmodial ... See more keywords
Preclinical evaluation of strasseriolides A–D, potent antiplasmodial macrolides isolated from Strasseria geniculata CF-247,251
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DOI: 10.1186/s12936-021-03993-8
Abstract: Background Malaria is a global health problem for which novel therapeutic compounds are needed. To this end, a recently published novel family of antiplasmodial macrolides, strasseriolides A – D , was herein subjected to in… read more here.
Keywords: evaluation strasseriolides; evaluation; preclinical evaluation; drug ... See more keywords