A Focused Library of NO‐Donor Compounds with Potent Antiproliferative Activity Based on Green Multicomponent Reactions
Sign Up to like & getrecommendations! Published in 2019 at "ChemMedChem"
DOI: 10.1002/cmdc.201900385
Abstract: Cancer is the second leading cause of death worldwide. Herein, a strategy to quickly and efficiently identify novel lead compounds to develop anticancer agents, using green multicomponent reactions followed by antiproliferative activity and structure–activity relationship… read more here.
Keywords: multicomponent reactions; green multicomponent; focused library; potent antiproliferative ... See more keywords
Design and synthesis of new indole containing biaryl derivatives as potent antiproliferative agents.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104821
Abstract: A new series of indole containing biaryl derivatives were designed and synthesized, and further biological evaluations of their antiproliferative activity against cancer cell lines (MGC-803 and TE-1 cells) were also conducted. Of these synthesized biaryls,… read more here.
Keywords: methyl; indole containing; potent antiproliferative; containing biaryl ... See more keywords
Identification of thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents through the drug repurposing strategy.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.04.056
Abstract: A series of thiazolo[5,4-d]pyrimidine derivatives were synthesized and evaluated for their antiproliferative activities on three cancer cell lines. The structure-activity relationship studies were conducted through the variation in the three regions of the thiazolo-pyrimidine core.… read more here.
Keywords: thiazolo pyrimidine; potent antiproliferative; identification thiazolo; pyrimidine derivatives ... See more keywords
Synthesis of a 3′-C-ethynyl-β-d-ribofuranose purine nucleoside library: Discovery of C7-deazapurine analogs as potent antiproliferative nucleosides
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DOI: 10.1016/j.ejmech.2018.07.062
Abstract: Abstract A focused nucleoside library was constructed around a 3′-C-ethynyl-d-ribofuranose sugar scaffold, which was coupled to variously modified purine nucleobases. The resulting nucleosides were probed for their ability to inhibit tumor cell proliferation, as well… read more here.
Keywords: deazapurine; potent antiproliferative; nucleoside library; ethynyl ribofuranose ... See more keywords
New binuclear Ni(II) metallates as potent antiproliferative agents against MCF-7 and HeLa cells
Sign Up to like & getrecommendations! Published in 2017 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2017.03.027
Abstract: Four new binuclear nickel(II) metallates 1-4 were synthesized from the reaction between NiCl2 center dot 6H(2)O, 1,3-bis(diphenylphosphino) propane and H2-(MSal-Rtsc)], where R = H, CH3, C2H5, C6H5, MSal = 3-methoxysalicylaldehyde, tsc = thiosemicarbazone. The complexes… read more here.
Keywords: potent antiproliferative; metallates potent; hela; binuclear metallates ... See more keywords