Generation and characterization of a high‐affinity chimeric anti‐OX40 antibody with potent antitumor activity
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14079
Abstract: OX40 is a costimulatory molecule that belongs to the tumor necrosis factor receptor (TNFR) superfamily. OX40 agonist‐based combinations are emerging as promising candidates for novel cancer immunotherapy. Clinical trials have shown that OX40 agonist antibodies… read more here.
Keywords: potent antitumor; ox40 antibody; chimeric anti; anti ox40 ... See more keywords
Potent antitumor effect of tumor microenvironment‐targeted oncolytic adenovirus against desmoplastic pancreatic cancer
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31060
Abstract: Pancreatic cancer is a leading cause of cancer‐related death. Desmoplastic pancreatic tumors exhibit excessive extracellular matrix (ECM) and are thus highly resistant to anticancer therapeutics, since the ECM restricts drug penetration and dispersion. Here, we… read more here.
Keywords: potent antitumor; desmoplastic pancreatic; pancreatic cancer; oncolytic adenovirus ... See more keywords
PD10-02 THE MTORC1/2 DUAL INHIBITOR AZD2014 WITH POTENT ANTITUMOR ACTIVITY IN DOCETAXEL SENSITIVE/RESISTANT PROSTATE CANCER IN VITRO
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000844.02
Abstract: INTRODUCTION AND OBJECTIVE:The mammalian target of rapamycin (mTOR) is a vital effect factor in regulating cell growth, survival and autophagy via direct interaction with mTORC1 (mTOR complex 1) an... read more here.
Keywords: pd10 mtorc1; mtorc1 dual; azd2014 potent; potent antitumor ... See more keywords
The discovery of a novel compound with potent antitumor activity: virtual screening, synthesis, biological evaluation and preliminary mechanism study
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15601
Abstract: Farnesyltransferase has been regarded as a promising drug target against cancer as it is critical for membrane association of several signal transduction proteins. In this study, a novel farnesyltransferase inhibitor (IMB-1406) was identified through virtual… read more here.
Keywords: virtual screening; potent antitumor; compound potent; antitumor activity ... See more keywords
A systemically administered detoxified TLR4 agonist displays potent antitumor activity and an acceptable tolerance profile in preclinical models
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1066402
Abstract: Bacterial lipopolysaccharides (LPS) are potent innate immunostimulants targeting the Toll-like receptor 4 (TLR4), an attractive and validated target for immunostimulation in cancer therapy. Although LPS possess anti-tumor activity, toxicity issues prevent their systemic administration at… read more here.
Keywords: administration; antitumor activity; tolerance profile; potent antitumor ... See more keywords