Azosemide is more potent than bumetanide and various other loop diuretics to inhibit the sodium-potassium-chloride-cotransporter human variants hNKCC1A and hNKCC1B
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DOI: 10.1038/s41598-018-27995-w
Abstract: The Na+–K+–2Cl− cotransporter NKCC1 plays a role in neuronal Cl− homeostasis secretion and represents a target for brain pathologies with altered NKCC1 function. Two main variants of NKCC1 have been identified: a full-length NKCC1 transcript… read more here.
Keywords: loop diuretics; cotransporter; potent bumetanide; azosemide potent ... See more keywords