Synthesis and evaluation of oxindoles as promising inhibitors of the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1.
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DOI: 10.1039/c7md00226b
Abstract: Indoleamine 2,3-dioxygenase 1 (IDO1) is considered as an important therapeutic target for the treatment of cancer, chronic infections and other diseases that are associated with immune suppression. Recent developments in understanding the catalytic mechanism of… read more here.
Keywords: ido1; ido1 enzyme; potent compounds; indoleamine dioxygenase ... See more keywords
Development of 4-[4-(Anilinomethyl)-3-phenyl-pyrazol-1-yl] Benzoic Acid Derivatives as Potent Anti-Staphylococci and Anti-Enterococci Agents
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DOI: 10.3390/antibiotics11070939
Abstract: From a library of compounds, 11 hit antibacterial agents have been identified as potent anti-Gram-positive bacterial agents. These pyrazole derivatives are active against two groups of pathogens, staphylococci and enterococci, with minimum inhibitory concentration (MIC)… read more here.
Keywords: potent compounds; anilinomethyl phenyl; development; development anilinomethyl ... See more keywords
Exploration of Potent Compounds with Glucokinase Activity for Diabetes Through Molecular Docking Analysis
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DOI: 10.52711/0974-360x.2024.00907
Abstract: Herbal medications are used to treat diseases and conditions with fewer adverse effects, ease of availability and low cost. So many bioactive compounds were identified from the plant, Andrographis paniculata . The objective of this… read more here.
Keywords: molecular docking; exploration potent; bioactive compounds; potent compounds ... See more keywords