Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
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DOI: 10.1021/acs.jmedchem.1c00339
Abstract: In immunoglobulin light-chain (LC) amyloidosis, transient unfolding or unfolding and proteolysis enable aggregation of LC proteins, causing potentially fatal organ damage. A drug that kinetically stabilizes LCs could suppress aggregation; however, LC sequences are variable… read more here.
Keywords: discovery potent; immunoglobulin; immunoglobulin light; potent coumarin ... See more keywords