Albumin nanoparticle encapsulation of potent cytotoxic therapeutics shows sustained drug release and alleviates cancer drug toxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c6cc08978j
Abstract: We here provide the first report on the construction of nanoparticles formulating highly potent cytotoxic therapeutics using albumin. Maytansinoid DM1 can be efficiently integrated into albumin nanoparticles, resulting in remarkable alleviation of in vivo drug… read more here.
Keywords: drug; drug toxicity; potent cytotoxic; cytotoxic therapeutics ... See more keywords
Abstract 1987: Delivery of potent cytotoxic camptothecin derivatives to tumors by OncoFAP-based small molecule-drug conjugates
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1987
Abstract: Small Molecule-Drug Conjugates (SMDCs) are anti-cancer pro-drugs composed by a tumor-targeting small organic ligand, a linker structure and a potent cytotoxic payload. OncoFAP is an ultra-high affinity ligand of Fibroblast Activation Protein (FAP), a stromal… read more here.
Keywords: small molecule; drug conjugates; potent; molecule drug ... See more keywords
Abietane Diterpenoids With Potent Cytotoxic Activities From the Resins of Populus euphratica
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DOI: 10.1177/1934578x19850029
Abstract: A new abietane norditerpenoid, 5-(6-isopropyl-2-methylnaphthalen-1-yl)pentan-2-one (1), with a rare 4,5-seco-19-norabietane skeleton possessing a rearranged angular methyl group at C-5, 2 new naturally occurring compounds, 19-norabieta-4,6,8,11,13-penttaen-3-one (2) and 14-hydroxy-7-oxo ester (3), along with 10 known analogs… read more here.
Keywords: diterpenoids potent; populus euphratica; cytotoxic activities; resins populus ... See more keywords
Potent Cytotoxic Analogs of Amphidinolides from the Atlantic Octocoral Stragulum bicolor
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DOI: 10.3390/md17010058
Abstract: Amphidinolides are cytotoxic macrolides produced by symbiotic unicellular microalgae of the genus Amphidinium. Here we describe the identification of four related molecules belonging to this macrolide family isolated from the invertebrate Stragulum bicolor. The new… read more here.
Keywords: stragulum bicolor; analogs amphidinolides; stragulum; cytotoxic analogs ... See more keywords
Discovery of a potent cytotoxic agent that promotes G2/M phase cell cycle arrest and apoptosis in a malignant human pharyngeal squamous carcinoma cell line.
Sign Up to like & getrecommendations! Published in 2022 at "International journal of oncology"
DOI: 10.3892/ijo.2022.5331
Abstract: Squamous cell carcinoma is the major form of malignancy that arises in head and neck cancer. The modest improvement in the 5‑year survival rate underpins its complex etiology and provides the impetus for the discovery… read more here.
Keywords: cell; cytotoxic agent; cell cycle; potent cytotoxic ... See more keywords