Cathepsin K is a potent disaggregase of α-synuclein fibrils.
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DOI: 10.1016/j.bbrc.2020.06.155
Abstract: The intracellular accumulation of α-synuclein (α-syn) amyloid fibrils is a hallmark of Parkinson's disease. Because lysosomes are responsible for degrading aggregated species, enhancing lysosomal function could alleviate the overburden of α-syn. Previously, we showed that… read more here.
Keywords: cathepsin potent; synuclein; syn; potent disaggregase ... See more keywords