Isosteroidal alkaloids as potent dual-binding site inhibitors of both acetylcholinesterase and butyrylcholinesterase from the bulbs of Fritillaria walujewii.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.06.007
Abstract: Five new isosteroidal alkaloids, walujewine A (1), walujewine B (4), walujewine C (5), walujewine D (6), walujewine E (10) were isolated from the bulbs of Fritillaria walujewii together with seven known isosteroidal alkaloids (2, 3,… read more here.
Keywords: alkaloids potent; potent dual; bulbs fritillaria; fritillaria walujewii ... See more keywords
Synthesis and Evaluation of 1,3,5-Triaryl-2-Pyrazoline Derivatives as Potent Dual Inhibitors of Urease and α-Glucosidase Together with Their Cytotoxic, Molecular Modeling and Drug-Likeness Studies
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DOI: 10.1021/acsomega.1c06694
Abstract: In the present work, a concise library of 1,3,5-triaryl-2-pyrazolines (2a–2q) was designed and synthesized by employing a multistep strategy, and the newly synthesized compounds were screened for their urease and α-glucosidase inhibitory activities. The compounds… read more here.
Keywords: dual inhibitors; glucosidase; urease glucosidase; potent dual ... See more keywords
Discovery of triterpenoids as potent dual inhibitors of pancreatic lipase and human carboxylesterase 1
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DOI: 10.1080/14756366.2022.2029855
Abstract: Abstract Pancreatic lipase (PL) is a well-known key target for the prevention and treatment of obesity. Human carboxylesterase 1A (hCES1A) has become an important target for the treatment of hyperlipidaemia. Thus, the discovery of potent… read more here.
Keywords: human carboxylesterase; hces1a; potent dual; pancreatic lipase ... See more keywords