Discovery of a Potent Grp94 Selective Inhibitor with Anti-Inflammatory Efficacy in a Mouse Model of Ulcerative Colitis.
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DOI: 10.1021/acs.jmedchem.8b00800
Abstract: As the endoplasmic reticulum paralogue of Hsp90, Grp94 chaperones a small set of client proteins associated with some diseases, including cancer, primary open-angle glaucoma, and inflammatory disorders. Grp94-selective inhibition has been a potential therapeutic strategy… read more here.
Keywords: grp94 selective; potent grp94; efficacy; mouse model ... See more keywords