Discovery of highly potent HDAC8 PROTACs with anti-tumor activity.
Sign Up to like & getrecommendations! Published in 2023 at "Bioorganic chemistry"
DOI: 10.2139/ssrn.4348732
Abstract: Various diseases are deeply associated with aberrations in HDAC8 functions. These aberrations can be assigned to either structural functions or catalytic functions of HDAC8. Therefore, development of HDAC8 degradation inducers might be more promising than… read more here.
Keywords: highly potent; hdac8; activity; potent hdac8 ... See more keywords