Identification of a potent heme oxygenase-2 (HO-2) inhibitor by targeting the secondary hydrophobic pocket of the HO-2 western region.
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DOI: 10.1016/j.bioorg.2020.104310
Abstract: The enzymatic family of heme oxygenase (HO) is accountable for heme breakdown. Among the two isoforms characterized to date, HO-2 is poorly investigated due to the lack of potent HO-2 chemical modulators and the greater… read more here.
Keywords: heme oxygenase; identification potent; western region; potent heme ... See more keywords