Discovery of potent IDO1 inhibitors derived from tryptophan using scaffold-hopping and structure-based design approaches.
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DOI: 10.1016/j.ejmech.2017.06.039
Abstract: Indoleamine 2,3-dioxygenase 1 (IDO1) is frequently hijacked by tumors to escape the host immune response, and the enzyme is now firmly established as an attractive target for cancer immunotherapy. To identify novel IDO1 inhibitors suitable… read more here.
Keywords: discovery potent; scaffold hopping; potent ido1; ido1 inhibitors ... See more keywords