Biocatalytic Production of a Potent Inhibitor of Adipocyte Differentiation from Phloretin Using Engineered CYP102A1.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.0c03156
Abstract: In this study, we investigated an efficient enzymatic strategy for producing potentially valuable phloretin metabolites from phlorizin, a glucoside of phloretin that is rich in apple pomace. Almond β-glucosidase efficiently removed phlorizin's glucose moiety to… read more here.
Keywords: potent inhibitor; phloretin; production; inhibitor adipocyte ... See more keywords
Potent Inhibitor of Human Trypsins from the Aeruginosin Family of Natural Products.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical biology"
DOI: 10.1021/acschembio.1c00611
Abstract: Serine proteases regulate many physiological processes and play a key role in a variety of cancers. Aeruginosins are a family of natural products produced by cyanobacteria that exhibit pronounced structural diversity and potent serine protease… read more here.
Keywords: potent inhibitor; inhibitor human; family natural; natural products ... See more keywords
S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth.
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.2210/pdb6gl8/pdb
Abstract: Escape from apoptosis is one of the major hallmarks of cancer cells. The B-cell Lymphoma 2 (BCL-2) gene family encodes pro-apoptotic and anti-apoptotic proteins that are key regulators of the apoptotic process. Overexpression of the… read more here.
Keywords: selective potent; potent inhibitor; s55746; novel orally ... See more keywords
A Helquat-like Compound as a Potent Inhibitor of Flaviviral and Coronaviral Polymerases
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27061894
Abstract: Positive-sense single-stranded RNA (+RNA) viruses have proven to be important pathogens that are able to threaten and deeply damage modern societies, as illustrated by the ongoing COVID-19 pandemic. Therefore, compounds active against most or many… read more here.
Keywords: compound potent; helquat like; rna; potent inhibitor ... See more keywords
The Antifungal Itraconazole Is a Potent Inhibitor of Chikungunya Virus Replication
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14071351
Abstract: Chikungunya virus (CHIKV) is the causative agent of chikungunya fever, a disabling disease that can cause long-term severe arthritis. Since the last large CHIKV outbreak in 2015, the reemergence of the virus represents a serious… read more here.
Keywords: chikungunya; chikungunya virus; replication; potent inhibitor ... See more keywords