Discovery of Potent and Isoform‐selective Histone Deacetylase Inhibitors Using Structure‐based Virtual Screening and Biological Evaluation
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DOI: 10.1002/minf.202100295
Abstract: Histone deacetylases (HDACs) are key enzymes in epigenetics and promising targets for anticancer therapy. Although several drugs targeting HDAC have been approved for the treatment of tumors, their clinical use has been limited by their… read more here.
Keywords: evaluation; isoform selective; histone; discovery potent ... See more keywords