New tranylcypromine derivatives containing sulfonamide motif as potent LSD1 inhibitors to target acute myeloid leukemia: Design, synthesis and biological evaluation.
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DOI: 10.1016/j.bioorg.2020.103808
Abstract: Lysine-specific demethylase 1 (LSD1) is frequently elevated in acute myeloid leukemia (AML) and often leads to tumorigenesis. In recent years, numerous LSD1 inhibitors based on tranylcypromine (TCP) scaffolding have reached clinical trials. Most TCP derivatives… read more here.
Keywords: myeloid leukemia; lsd1 inhibitors; acute myeloid; lsd1 ... See more keywords