Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.01.005
Abstract: Summary Respiratory syncytial virus (RSV) is a leading cause of infant mortality, and there are currently no licensed vaccines to protect this vulnerable population. A comprehensive understanding of infant antibody responses to natural RSV infection… read more here.
Keywords: respiratory syncytial; lack somatic; potent neutralizing; rsv ... See more keywords
Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries
Sign Up to like & getrecommendations! Published in 2021 at "Cell Discovery"
DOI: 10.1038/s41421-021-00295-w
Abstract: As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to threaten public health worldwide, the development of effective interventions is urgently needed. Neutralizing antibodies (nAbs) have great potential for the prevention and treatment of… read more here.
Keywords: phage display; potent neutralizing; neutralizing antibodies; convalescent patients ... See more keywords
Discovery and characterization of potent IL-21 neutralizing antibodies via a novel alternating antigen immunization and humanization strategy
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0211236
Abstract: Interleukin-21 (IL-21), a member of the common cytokine receptor γ chain (γc) family, is secreted by CD4+ T cells and natural killer T cells and induces effector function through interactions with the IL-21 receptor (IL-21R)/γc… read more here.
Keywords: immunization; novel alternating; potent neutralizing; neutralizing antibodies ... See more keywords
Potent Neutralizing Humanized Antibody With Topical Therapeutic Potential Against HPV18-Related Cervical Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.678318
Abstract: Cervical cancer caused by human papillomavirus (HPV) infections is the fourth most common cancer in women worldwide. Current prophylactic HPV vaccines have achieved promising success in preventing HPV infection. However, still 570,000 new cases were… read more here.
Keywords: infection; cervical cancer; potent neutralizing; hpv18 related ... See more keywords