Scaffold Hybrid of the Natural Product Tanshinone I with Piperidine for the Discovery of a Potent NLRP3 Inflammasome Inhibitor.
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DOI: 10.1021/acs.jmedchem.2c01967
Abstract: Natural products provide inspiration and have proven to be the most valuable source for drug discovery. Herein, we report a scaffold hybrid strategy of Tanshinone I for the discovery of NLRP3 inflammasome inhibitors. 36 compounds… read more here.
Keywords: potent nlrp3; tanshinone; scaffold hybrid; discovery ... See more keywords