Efficacy and safety of potent platelet P2Y12 receptor inhibitors in elderly versus nonelderly patients with acute coronary syndrome: A systematic review and meta‐analysis
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DOI: 10.1016/j.ahj.2017.09.012
Abstract: Background The use of the potent oral P2Y12 inhibitors prasugrel and ticagrelor in patients with acute coronary syndromes (ACS) has a favorable net clinical effect compared with clopidogrel and is recommended as first‐line therapy. However,… read more here.
Keywords: p2y12; safety; efficacy; nonelderly patients ... See more keywords
Effects of potent P2Y12 inhibitors in patients who survived from acute myocardial infarction complicated by cardiogenic shock
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DOI: 10.1093/ehjacc/zuaf044.228
Abstract: Although two pivotal trials including PLATO and TRITON-TIMI 38 consistently demonstrated that the ischemic benefits of potent P2Y12 inhibitors (prasugrel or ticagrelor) over clopidogrel in patients with acute myocardial infarction (AMI), those trials exclude patients… read more here.
Keywords: potent p2y12; p2y12 inhibitors; patients ami; complicated cardiogenic ... See more keywords
Elderly patients are hyperresponsive to potent P2Y12 inhibitors
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DOI: 10.1093/eurheartj/ehae666.1422
Abstract: Aging has recently been associated with increased basal platelet activation and adenosine diphosphate (ADP) hyperreactivity on the one hand, but decreased platelet response to thrombin receptor stimulation on the other hand in individuals without antiplatelet… read more here.
Keywords: potent p2y12; platelet aggregation; response; elderly patients ... See more keywords
Risk of ischaemic and haemorrhagic stroke in Chinese undergoing percutaneous coronary intervention treated with potent P2Y12 inhibitor versus clopidogrel
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DOI: 10.1136/svn-2021-001294
Abstract: Background Stroke after acute coronary syndrome (ACS) can be devastating. It is uncertain whether the risks of ischaemic stroke or intracranial haemorrhage (ICH) are associated with different choices of P2Y12 inhibitors (potent P2Y12 inhibitors such… read more here.
Keywords: potent p2y12; ischaemic stroke; clopidogrel; risk ... See more keywords
Potent P2Y12 inhibitors in patients with acute myocardial infarction and cardiogenic shock
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DOI: 10.1186/s13054-025-05277-y
Abstract: Although potent P2Y12 inhibitors, such as ticagrelor and prasugrel, are standard treatment in patients with acute myocardial infarction (AMI), evidence for their efficacy and safety compared with clopidogrel is limited in patients with AMI complicated… read more here.
Keywords: cardiogenic shock; inhibitors patients; potent p2y12; p2y12 inhibitors ... See more keywords
Potent P2Y12 inhibitors versus clopidogrel to predict adherence to antiplatelet therapy after an acute coronary syndrome: insights from IDEAL-LDL.
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DOI: 10.31083/j.rcm2303081
Abstract: BACKGROUND Superiority of potent P2Y12 inhibitors over clopidogrel after an acute coronary syndrome (ACS) has been well established, however potent P2Y12 inhibition is responsible for more adverse events, which may influence patient adherence to treatment.… read more here.
Keywords: adherence; potent p2y12; potent; therapy ... See more keywords
Unguided De-Escalation Strategy From Potent P2Y12 Inhibitors in Patients Presented With ACS: When, Whom and How?
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DOI: 10.4070/kcj.2022.0022
Abstract: https://e-kcj.org In patients with acute coronary syndrome (ACS) treated with percutaneous coronary intervention (PCI), dual antiplatelet therapy (DAPT) is an essential strategy of their management. According to the current guidelines, it is generally recommended to… read more here.
Keywords: unguided escalation; strategy; escalation strategy; potent p2y12 ... See more keywords