Design, synthesis and evaluation of phthalazinone thiohydantoin-based derivative as potent PARP-1 inhibitors.
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DOI: 10.1016/j.bioorg.2019.103181
Abstract: Two new series of compounds were designed and synthesized as potent PARP-1 inhibitors. These compounds were evaluated for PARP-1 enzyme and cellular inhibitory activities. All efforts lead to the identification of 9k (named as LG-12)… read more here.
Keywords: parp inhibitors; design synthesis; potent parp; evaluation ... See more keywords