Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights.
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DOI: 10.1080/17568919.2024.2342707
Abstract: Aim: Synthesis of novel bis-Schiff bases having potent inhibitory activity against phosphodiesterase (PDE-1 and -3) enzymes, potentially offering therapeutic implications for various conditions. Methods: Bis-Schiff bases were synthesized by refluxing 2,4-dihydroxyacetophenone with hydrazine hydrate, followed… read more here.
Keywords: dihydroxyacetophenone; potent pde; dihydroxyacetophenone derivatives; synthesis ... See more keywords