Discovery of BIIB068: A Selective, Potent, Reversible Bruton's Tyrosine Kinase Inhibitor as an Orally Efficacious Agent for Autoimmune Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00702
Abstract: Autoreactive B cell-derived antibodies form immune-complexes that likely play a pathogenic role in autoimmune diseases. In Systemic Lupus Erythematosus (SLE), these antibodies bind Fc receptors on myeloid cells and induce proinflammatory cytokine production by monocytes… read more here.
Keywords: potent reversible; kinase; autoimmune diseases; bruton tyrosine ... See more keywords
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
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DOI: 10.2210/pdb6rua/pdb
Abstract: Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer’s disease (AD) in its advanced stages. It also potentially represents a biomarker for pr... read more here.
Keywords: development potent; selective inhibitors; potent reversible; inhibitors butyrylcholinesterase ... See more keywords