Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity.
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DOI: 10.1016/j.ejmech.2021.114036
Abstract: RIPK1 plays a key role in the necroptosis pathway that regulates inflammatory signaling and cell death in various diseases, including inflammatory and neurodegenerative diseases. Herein, we report a series of potent RIPK1 inhibitors, represented by… read more here.
Keywords: potent ripk1; design synthesis; ripk1; compound ... See more keywords