Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants
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DOI: 10.1038/s41467-021-26539-7
Abstract: Accumulating mutations in the SARS-CoV-2 Spike (S) protein can increase the possibility of immune escape, challenging the present COVID-19 prophylaxis and clinical interventions. Here, 3 receptor binding domain (RBD) specific monoclonal antibodies (mAbs), 58G6, 510A5… read more here.
Keywords: efficacy; cov neutralizing; neutralizing antibodies; potent sars ... See more keywords
Potent SARS-CoV-2 binding and neutralization through maturation of iconic SARS-CoV-1 antibodies
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DOI: 10.1080/19420862.2021.1922134
Abstract: ABSTRACT Antibodies against coronavirus spike protein potently protect against infection and disease, but whether such protection can be extended to variant coronaviruses is unclear. This is exemplified by a set of iconic and well-characterized monoclonal… read more here.
Keywords: maturation; cov binding; antibody; potent sars ... See more keywords
Chloropyridinyl Esters of Nonsteroidal Anti-Inflammatory Agents and Related Derivatives as Potent SARS-CoV-2 3CL Protease Inhibitors
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DOI: 10.3390/molecules26195782
Abstract: We report the design and synthesis of a series of new 5-chloropyridinyl esters of salicylic acid, ibuprofen, indomethacin, and related aromatic carboxylic acids for evaluation against SARS-CoV-2 3CL protease enzyme. These ester derivatives were synthesized… read more here.
Keywords: cov 3cl; chloropyridinyl esters; cov 3clpro; 3cl protease ... See more keywords