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Discovery of a Novel Series of Imidazopyrazine Derivatives as Potent SHP2 Allosteric Inhibitors.

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1 Published in 2023 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.2c00454

Abstract: Protein tyrosine phosphatase SHP2 is an oncogenic protein that can regulate different cytokine receptor and receptor tyrosine kinase signaling pathways. We report here the identification of a novel series of SHP2 allosteric inhibitors having an… read more here.

Keywords: novel series; discovery novel; potent shp2; shp2 allosteric ... See more keywords

Discovery of a Novel Series of Potent SHP2 Allosteric Inhibitors.

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recommendations!
2 Published in 2023 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.3c00059

Abstract: Src homology 2-containing protein tyrosine phosphatase 2 (SHP2) is the first reported nonreceptor oncogenic tyrosine phosphatase connecting multiple signal transduction cascades and exerting immunoinhibitory function through the PD-1 checkpoint receptor. As part of a drug… read more here.

Keywords: novel series; discovery novel; series; potent shp2 ... See more keywords