The Search for Potent, Small‐Molecule HDACIs in Cancer Treatment: A Decade After Vorinostat
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Research Reviews"
DOI: 10.1002/med.21437
Abstract: Histone deacetylases (HDACs) play a crucial role in the remodeling of chromatin, and are involved in the epigenetic regulation of gene expression. In the last decade, inhibition of HDACs came out as a target for… read more here.
Keywords: treatment; potent small; decade; cancer ... See more keywords
A comparative study of the recent most potent small-molecule PD-L1 inhibitors: what can we learn?
Sign Up to like & getrecommendations! Published in 2021 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-021-02728-3
Abstract: Immune checkpoint inhibitors targeting the PD-1/PD-L1 pathway have become a “game-changer” in the cancer treatment. However, none of the small molecular inhibitors has been approved yet. To explore the advantages and disadvantages of various scaffolds,… read more here.
Keywords: incyte 011; study recent; comparative study; potent small ... See more keywords
Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00013
Abstract: Ubiquitin-specific protease 8 (USP8), belonging to the deubiquitinase family, has been implicated to be closely related to the occurrence of many malignant tumors, but only a few USP8-targeting inhibitors have been reported to date. In… read more here.
Keywords: small molecule; discovery potent; breast; breast cancer ... See more keywords
Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.
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DOI: 10.1021/acschembio.2c00843
Abstract: WD repeat domain 5 (WDR5) is a member of the WD40-repeat protein family that plays a critical role in multiple processes. It is also a prominent target for pharmacological inhibition in diseases such as cancer,… read more here.
Keywords: interaction; wdr5; discovery potent; molecule ... See more keywords
Discovery of Highly Potent Small Molecule Pan-Coronavirus Fusion Inhibitors
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DOI: 10.3390/v15041001
Abstract: The unprecedented pandemic of COVID-19, caused by a novel coronavirus, SARS-CoV-2, has led to massive human suffering, death, and economic devastation worldwide. The virus is mutating fast to more transmissible and infectious variants. The Delta… read more here.
Keywords: pan coronavirus; highly potent; coronavirus; potent small ... See more keywords