Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study
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DOI: 10.1080/14756366.2022.2076674
Abstract: sABSTRACT TANK-binding kinase 1 (TBK1), a noncanonical member of the inhibitor-kappaB kinases (IKKs) family, plays a vital role in coordinating the signalling pathways of innate immunity, involving in the process of neuroinflammation, autophagy, and oncogenesis.… read more here.
Keywords: tbk1; pyrazolo pyridine; tbk1 inhibitors; pyridine derivatives ... See more keywords