Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5H88Y Mutant Mice.
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DOI: 10.1021/acs.jmedchem.1c00851
Abstract: Takeda G protein-coupled receptor 5 (TGR5) is a promising target for treating metabolic syndrome and inflammatory diseases. Herein, we identified a new series of betulinic acid derivatives as potent TGR5 agonists, which show remarkable activity… read more here.
Keywords: potent tgr5; derivatives potent; betulinic acid; acid derivatives ... See more keywords