LAUSR

Potent Uncompetitive Inhibitors of Nicotinamide N-Methyltransferase (NNMT) as In Vivo Chemical Probes.

Sign Up to like & get
recommendations!
1 Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.2c01166

Abstract: NNMT uses SAM as a cofactor to catalyze the methylation of nicotinamide, producing 1-methylnicotinamide. Recent studies have shown that NNMT upregulation in cancer-associated fibroblasts (CAFs) is required to maintain the CAF phenotype in high-grade serous… read more here.

Keywords: potent uncompetitive; chemical probes; uncompetitive inhibitors; nicotinamide methyltransferase ... See more keywords