Hydrazine clubbed 1,3-thiazoles as potent urease inhibitors: design, synthesis and molecular docking studies
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10057-7
Abstract: Abstract Synthesis of a novel series of hydrazine clubbed 1,3-thiazoles ( 5a–m ) has been described by reacting hydrazine-1-carbothioamides ( 3a–k ) with α -chloro- or bromo-acetophenones ( 4a–d ) in refluxing ethanol in good… read more here.
Keywords: urease inhibitors; clubbed thiazoles; potent urease; hydrazine clubbed ... See more keywords
Arylamino containing hydroxamic acids as potent urease inhibitors for the treatment of Helicobacter pylori infection.
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DOI: 10.1016/j.ejmech.2018.06.065
Abstract: A novel series of aniline-containing hydroxamic acids were designed, synthesized and evaluated as anti-virulence agents for the treatment of gastritis and gastric ulcer caused by Helicobacter pylori. In vitro enzyme-based screen together with in vivo assays and… read more here.
Keywords: containing hydroxamic; urease inhibitors; treatment; potent urease ... See more keywords
N-monoarylacetothioureas as potent urease inhibitors: synthesis, SAR, and biological evaluation
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2019.1706503
Abstract: Abstract A urease inhibitor with good in vivo profile is considered as an alternative agent for treating infections caused by urease-producing bacteria such as Helicobacter pylori. Here, we report a series of N-monosubstituted thioureas, which… read more here.
Keywords: inhibitors synthesis; synthesis sar; sar biological; urease inhibitors ... See more keywords