Spotlight on 4‐substituted quinolines as potential anti‐infective agents: Journey beyond chloroquine
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200361
Abstract: Continued emerging resistance of pathogens against the clinically approved candidates and their associated limitations continuously demand newer agents having better potency with a more suited safety profile. Quinoline nuclei containing scaffolds of natural and synthetic… read more here.
Keywords: infective agents; anti infective; substituted quinolines; quinolines potential ... See more keywords
Design of potential anti-tumor PARP-1 inhibitors by QSAR and molecular modeling studies
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Diversity"
DOI: 10.1007/s11030-020-10063-9
Abstract: Abstract Poly ADP-ribose polymerase-1 (PARP-1) inhibitors have been recognized as new agents for the treatment of patients with breast cancer type 1 (BRCA1) disorders. The quantitative structure–activity relationships (QSAR) technique was used in order to… read more here.
Keywords: parp inhibitors; design potential; potential anti; anti tumor ... See more keywords
Potential anti-neuroblastoma agents from Juniperus oblonga.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.06.123
Abstract: Neuroblastoma (NB) is a neuroendocrine tumor derived from neural crest cells. Approximately 90% of cases occur in children less than 5 years old. The amplification of MYCN correlates with high-risk neuroblastoma and patients with MYCN… read more here.
Keywords: cell; neuroblastoma; potential anti; anti neuroblastoma ... See more keywords
Design, synthesis, and biological evaluation of novel dual FFA1 (GPR40)/PPARδ agonists as potential anti-diabetic agents.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.103254
Abstract: The free fatty acid receptor 1 (FFA1) and peroxisome proliferator-activated receptor δ (PPARδ) were considered as potential anti-diabetic targets, and the dual FFA1/PPARδ agonists might provide synergistic effect in insulin secretion and sensibility. Herein, we… read more here.
Keywords: ppar; ppar agonists; ffa1; potential anti ... See more keywords
Design, synthesis and biological evaluation of potential anti-AD hybrids with monoamine oxidase B inhibitory and iron-chelating effects.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104564
Abstract: A series of active hybrids combining 3-hydroxypyridin-4(1H)-one and coumarin pharmacophores were designed and synthesized as potential agents for the treatment of Alzheimer's disease (AD). All the compounds exhibited excellent iron-chelating activities (pFe3+ = 14.8-19.2) and… read more here.
Keywords: iron chelating; potential anti; monoamine oxidase; inhibitory ... See more keywords
Synergistic integration of dihydro-artemisinin with γ-aminobutyric acid results in a more potential anti-depressant.
Sign Up to like & getrecommendations! Published in 2021 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2021.104769
Abstract: Three hybrids of dihydro-artemisinin (DHA) with β-aminopropionic acid, γ-aminobutyric acid, and histamine have been designed and synthesized. The conjugate of DHA with GABA labelled as 5b was confirmed the most active candidate against both Cort-… read more here.
Keywords: anti depressant; potential anti; dihydro artemisinin; acid ... See more keywords
Synthesis and biological evaluation of novel isoxazole-piperazine hybrids as potential anti-cancer agents with inhibitory effect on liver cancer stem cells.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113489
Abstract: In our effort for the development of novel anticancer therapeutics, a series of isoxazole-piperazine analogues were prepared, and primarily screened for their antiproliferative potential against hepatocellular carcinoma (HCC; Huh7/Mahlavu) and breast (MCF-7) cancer cells. All… read more here.
Keywords: isoxazole piperazine; potential anti; novel isoxazole; cancer ... See more keywords
Potential anti-diabetic isoprenoids and a long-chain δ-lactone from frangipani (Plumeria rubra).
Sign Up to like & getrecommendations! Published in 2020 at "Fitoterapia"
DOI: 10.1016/j.fitote.2020.104684
Abstract: A decoction of Plumeria rubra flowers has been used traditionally for the treatment of diabetes in China and Mexico. Chemical investigations on the bioactive constituents of these flowers led to the isolation of 30 compounds,… read more here.
Keywords: potential anti; long chain; anti diabetic; chain lactone ... See more keywords
Qualitative elemental analysis of selected potential anti-asthmatic medicinal plant taxa using EDXRF technique
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e03260
Abstract: Qualitative elemental analysis was determined in various parts of potential anti-asthmatic medicinal plants using Energy Dispersive X-ray Fluorescence (EDXRF) spectrometer. X-ray beam was used to excite each sample and spectra were recorded with a high… read more here.
Keywords: asthmatic medicinal; anti asthmatic; analysis; potential anti ... See more keywords
Potential anti-arthritic and anti-inflammatory effects of TNF-α processing inhibitor-1 (TAPI-1): A new approach to the treatment of S. aureus arthritis.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.11.022
Abstract: Treatment of septic arthritis has become more challenging due to the rise of multidrug resistant strains of Staphylococcus aureus (S. aureus) in recent years. Failure of antibiotic therapies has compelled to initiate the search for… read more here.
Keywords: anti arthritic; inhibitor; tnf processing; treatment ... See more keywords
Potential anti-Alzheimer effects of selected Lamiaceae plants through polypharmacology on glycogen synthase kinase-3β, β-secretase, and casein kinase 1δ
Sign Up to like & getrecommendations! Published in 2019 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2019.05.080
Abstract: Abstract The aerial parts of Lamiaceae plants have been used since ancient times all over the world, especially in Mediterranean cultures, for their medicinal and culinary properties. Although some of them have a historical role… read more here.
Keywords: kinase; anti alzheimer; alzheimer effects; potential anti ... See more keywords