Design, Synthesis, and Dual Evaluation of Quinoline and Quinolinium Iodide Salt Derivatives as Potential Anticancer and Antibacterial Agents
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DOI: 10.1002/cmdc.202000002
Abstract: A series of novel quinoline and quinolinium iodide derivatives were designed and synthesized to discover potential anticancer and antibacterial agents. With regard to anticancer properties, in vitro cytotoxicities against three human cancer cell lines (A‐549, HeLa… read more here.
Keywords: quinolinium iodide; quinoline quinolinium; antibacterial agents; anticancer antibacterial ... See more keywords
A comprehensive review of antitumor properties of Angelica species and their antitumor‐responsible constituents and the underlying molecular mechanisms involved in tumor inhibition
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DOI: 10.1002/ptr.7841
Abstract: Angelica species have been traditionally used for their medicinal properties. Recent studies have suggested their potential use as anticancer agents, making them an area of interest for further research. The review aims to summarize the… read more here.
Keywords: potential anticancer; antitumor; review; angelica species ... See more keywords
Itaconic acid hybrids as potential anticancer agents
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DOI: 10.1007/s11030-020-10147-6
Abstract: Abstract In this paper, we report the synthesis of novel hybrids 2–14 based on itaconic acid and fluoroaniline, pyridine, indole and quinoline scaffolds. Itaconic acid is a naturally occurring compound with a Michael acceptor moiety,… read more here.
Keywords: anticancer agents; itaconic acid; acid hybrids; hybrids potential ... See more keywords
Potential anticancer applications of the novel naringin-based ruthenium (II) complex
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DOI: 10.1007/s13205-019-1718-4
Abstract: Ruthenium seems to be a promising alternative to platinum because of the wide range of oxidation states it has and its ability to form complexes with bioactive ligands. In this study, naringin, a naturally occurring… read more here.
Keywords: ruthenium; complex potential; anticancer applications; ruthenium complex ... See more keywords
Discovery of [1,2,4]triazolo[1,5-a]pyrimidines derivatives as potential anticancer agents.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.113108
Abstract: In this work, we reported the discovery of compound 6i with potent antiproliferative activity against MGC-803. Among these compounds, the most potent compound 6i could effectively inhibit MGC-803 (IC50 = 0.96 μM), being around 38-fold selectivity over GES-1.… read more here.
Keywords: mgc 803; discovery triazolo; triazolo pyrimidines; derivatives potential ... See more keywords
β-Carbolines as potential anticancer agents.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113321
Abstract: β-Carbolines are indole alkaloids having a tricyclic pyrido[3,4-b]indole ring in their structure. Since the isolation of first β-carboline from Peganum harmala in 1841, the isolation and synthesis of various β-carboline derivatives surged in the following… read more here.
Keywords: carbolines potential; anticancer agents; chemistry; anticancer ... See more keywords
Efficient Synthesis and Bioevaluation of Novel Dual Tubulin/Histone Deacetylase 3 Inhibitors as Potential Anticancer Agents.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00413
Abstract: Novel dual HDAC3/tubulin inhibitors were designed and efficiently synthesized by combining the pharmacophores of SMART (tubulin inhibitor) and MS-275 (HDAC inhibitor), among which compound 15c was found to be the most potent and balanced HDAC3/tubulin… read more here.
Keywords: compound 15c; novel dual; cancer cell; tubulin ... See more keywords
Design, Synthesis, and Biological Evaluation of Stable Colchicine-Binding Site Tubulin Inhibitors 6-Aryl-2-benzoyl-pyridines as Potential Anticancer Agents.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c00715
Abstract: We previously reported a potent tubulin inhibitor CH-2-77. In this study, we optimized the structure of CH-2-77 by blocking metabolically labile sites and synthesized a series of CH-2-77 analogues. Two compounds, 40a and 60c, preserved… read more here.
Keywords: tubulin; binding site; colchicine binding; potential anticancer ... See more keywords
Ruthenium-nitrosyl complexes as NO-releasing molecules, potential anticancer drugs, and photoswitches based on linkage isomerism.
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DOI: 10.1039/d2dt00290f
Abstract: The synthesis of new types of mono- and polynuclear ruthenium nitrosyl complexes is driving progress in the field of NO generation for a variety of applications. Light-induced Ru-NO bond dissociation in solution may involve transient… read more here.
Keywords: potential anticancer; nitrosyl complexes; ruthenium nitrosyl; anticancer drugs ... See more keywords
New 1,3,4-thiadiazoles as potential anticancer agents: pro-apoptotic, cell cycle arrest, molecular modelling, and ADMET profile
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DOI: 10.1039/d3ra02716c
Abstract: A series of novel 1,3,4-thiadiazoles was synthesized via the reaction of N-(5-(2-cyanoacetamido)-1,3,4-thiadiazol-2-yl)benzamide (3) with different carbon electrophiles and evaluated as potential anticancer agents. The chemical structures of these derivatives were fully elucidated using various spectral… read more here.
Keywords: potential anticancer; agents pro; thiadiazoles potential; new thiadiazoles ... See more keywords
Synthesis of Naphthoic Acids as Potential Anticancer Agents
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DOI: 10.1055/s-0037-1611342
Abstract: As part of ongoing research to investigate structural requirements for lactate dehydrogenase inhibition by highly substituted naphthoic acids, nine new aryl-substituted dihydroxynaphthoic acids were synthesized from three known precursors. Described here are efficient preparations of… read more here.
Keywords: anticancer agents; acids potential; synthesis naphthoic; naphthoic acids ... See more keywords