Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads.
Sign Up to like & getrecommendations! Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-00349-9
Abstract: Aspergillus fumigatus is a fungal pathogen whose effects can be debilitating and potentially fatal in immunocompromised patients. Current drug treatment options for this infectious disease are limited to just a few choices (e.g. voriconazole and… read more here.
Keywords: aspergillus fumigatus; acetohydroxyacid synthase; drug; antifungal drug ... See more keywords
Peptaibols as Potential Antifungal and Anticancer Antibiotics: Current and Foreseeable Development (Review)
Sign Up to like & getrecommendations! Published in 2021 at "Applied Biochemistry and Microbiology"
DOI: 10.1134/s0003683821050070
Abstract: Today’s shortage of effective antimicrobial agents can be overcome by using antimicrobial peptides, which are produced naturally by a wide range of organisms, including microorganisms, plants, and mammals. Among these chemical groups, peptaibols are the… read more here.
Keywords: peptaibols potential; antifungal anticancer; anticancer antibiotics; antibiotics current ... See more keywords
Potential Antifungal Targets Based on Glucose Metabolism Pathways of Candida albicans
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2020.00296
Abstract: In recent years, fungal infections have become a serious health problem. Candida albicans are considered as the fourth most common isolates associated with approximately 40% mortality in bloodstream infections among hospitalized patients. Due to various… read more here.
Keywords: metabolism pathways; metabolism; candida albicans; glucose metabolism ... See more keywords
Rhein–Amino Acid Ester Conjugates as Potential Antifungal Agents: Synthesis and Biological Evaluation
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DOI: 10.3390/molecules28052074
Abstract: In the search for crop protectants, amino acid ester conjugates have been widely investigated as potential antifungal agents. In this study, a series of rhein–amino acid ester conjugates were designed and synthesized in good yields,… read more here.
Keywords: ester conjugates; potential antifungal; amino acid; acid ester ... See more keywords