Triazolopyrimidine herbicides are potent inhibitors of Aspergillus fumigatus acetohydroxyacid synthase and potential antifungal drug leads.
Sign Up to like & getrecommendations! Published in 2021 at "Scientific reports"
DOI: 10.1038/s41598-021-00349-9
Abstract: Aspergillus fumigatus is a fungal pathogen whose effects can be debilitating and potentially fatal in immunocompromised patients. Current drug treatment options for this infectious disease are limited to just a few choices (e.g. voriconazole and… read more here.
Keywords: aspergillus fumigatus; acetohydroxyacid synthase; drug; antifungal drug ... See more keywords
Evaluation of Satanin 1 as a potential antifungal antimicrobial peptide to treat Malassezia infections
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DOI: 10.1038/s41598-025-99464-0
Abstract: Malassezia is a fungal genus that is part of the skin’s normal mycobiota but can also cause various diseases. The emergence of resistance to antimicrobial agents in several microorganisms, including Malassezia yeasts, has led to… read more here.
Keywords: antimicrobial peptide; evaluation satanin; potential antifungal; satanin potential ... See more keywords
Design, Synthesis, and In Silico Studies of 1,2,3-Triazole-Linked Coumarin–Chalcone Hybrids as Potential Antifungal Agents
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DOI: 10.1055/a-2577-0837
Abstract: Fungal infections are a growing global health concern due to their rising incidence and increasing resistance to existing drugs. With the aim of developing new antifungal candidates, this study introduces a series of novel coumarin–chalcone… read more here.
Keywords: antifungal agents; chalcone hybrids; triazole linked; potential antifungal ... See more keywords
Peptaibols as Potential Antifungal and Anticancer Antibiotics: Current and Foreseeable Development (Review)
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DOI: 10.1134/s0003683821050070
Abstract: Today’s shortage of effective antimicrobial agents can be overcome by using antimicrobial peptides, which are produced naturally by a wide range of organisms, including microorganisms, plants, and mammals. Among these chemical groups, peptaibols are the… read more here.
Keywords: peptaibols potential; antifungal anticancer; anticancer antibiotics; antibiotics current ... See more keywords
Potential Antifungal Targets Based on Glucose Metabolism Pathways of Candida albicans
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DOI: 10.3389/fmicb.2020.00296
Abstract: In recent years, fungal infections have become a serious health problem. Candida albicans are considered as the fourth most common isolates associated with approximately 40% mortality in bloodstream infections among hospitalized patients. Due to various… read more here.
Keywords: metabolism pathways; metabolism; candida albicans; glucose metabolism ... See more keywords
The potential of the antifungal nystatin to be repurposed to fight the protozoan Trypanosoma cruzi
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1539629
Abstract: Chagas disease, caused by the parasite Trypanosoma cruzi, affects 6 million people worldwide. Although the drugs benznidazole (BZN) and nifurtimox are available to treat Chagas, they are not effective in the chronic phase when most… read more here.
Keywords: antifungal nystatin; potential antifungal; drug; trypanosoma cruzi ... See more keywords
Characterization of a New Hsp110 Inhibitor as a Potential Antifungal
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Fungi"
DOI: 10.3390/jof10110732
Abstract: Fungal infections present a significant global health challenge, prompting ongoing research to discover innovative antifungal agents. The 110 kDa heat shock proteins (Hsp110s) are molecular chaperones essential for maintaining cellular protein homeostasis in eukaryotes. Fungal… read more here.
Keywords: hsp110 inhibitor; potential antifungal; inhibitor potential; hsp110 ... See more keywords
Rhein–Amino Acid Ester Conjugates as Potential Antifungal Agents: Synthesis and Biological Evaluation
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28052074
Abstract: In the search for crop protectants, amino acid ester conjugates have been widely investigated as potential antifungal agents. In this study, a series of rhein–amino acid ester conjugates were designed and synthesized in good yields,… read more here.
Keywords: ester conjugates; potential antifungal; amino acid; acid ester ... See more keywords