Amino-Substituted 3-Aryl- and 3-Heteroarylquinolines as Potential Antileishmanial Agents
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c00813
Abstract: Leishmaniasis, a disease caused by protozoa of the Leishmania species, afflicts roughly 12 million individuals worldwide. Most existing drugs for leishmaniasis are toxic, expensive, difficult to administer, and subject to drug resistance. We report a… read more here.
Keywords: heteroarylquinolines potential; substituted aryl; potential antileishmanial; aryl heteroarylquinolines ... See more keywords
A Triazole Hybrid of Neolignans as a Potential Antileishmanial Agent by Triggering Mitochondrial Dysfunction.
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules25010037
Abstract: In the search for new compounds with antileishmanial activity, we synthesized a triazole hybrid analogue of the neolignans grandisin and machilin G (LASQUIM 25), which was previously found highly active against both promastigotes and intracellular… read more here.
Keywords: hybrid neolignans; antileishmanial agent; neolignans potential; potential antileishmanial ... See more keywords