Synthesis of unprecedented steroidal spiro heterocycles as potential antiproliferative drugs.
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DOI: 10.1016/j.ejmech.2017.10.063
Abstract: Herein we report the straightforward preparation of novel conformationally-restricted steroids from trans-androsterone and estrone, decorated with spiranic oxazolidin-2-one or 2-aminooxazoline motifs at C-17 as potential antiproliferative agents. Such unprecedented pharmacophores were accessed using an aminomethylalcohol… read more here.
Keywords: steroidal spiro; cell lines; potential antiproliferative; unprecedented steroidal ... See more keywords
Carbazole alkaloids from Clausena emarginata with their potential antiproliferative activities
Sign Up to like & getrecommendations! Published in 2018 at "Natural Product Research"
DOI: 10.1080/14786419.2018.1475386
Abstract: Abstract A phytochemical investigation on the stems and leaves of Clausena emarginata led to the isolation of a previously undescribed carbazole alkaloid, clausemargine A (1), together with 11 known analogues (2–12). The structure of 1… read more here.
Keywords: emarginata potential; clausena emarginata; alkaloids clausena; antiproliferative activities ... See more keywords
Anthraquinones with potential antiproliferative activities from the fruits of Morinda citrifolia.
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DOI: 10.1080/14786419.2021.2012670
Abstract: The phytochemical investigation on the fruits of Morinda citrifolia led to the isolation and characterization of a new anthraquinone, moricitrifone (1), along with seven known anthraquinones (2-8). The chemical structure of 1 was elucidated by… read more here.
Keywords: antiproliferative activities; fruits morinda; potential antiproliferative; anthraquinones potential ... See more keywords
10β-Hydroxyestra-1,4-diene-3,17-dione as potential antiproliferative agent: in vitro biological evaluation and in silico studies
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DOI: 10.1080/14786419.2022.2039136
Abstract: Abstract 10β-Hydroxyestra-1,4-diene-3,17-dione (HEDD) is a natural product described as having neuroprotective activity. However, the cytotoxic properties of this quinol are barely studied. Thus, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was performed in six cell lines (MCF-7, T47-D,… read more here.
Keywords: antiproliferative agent; hydroxyestra diene; diene dione; potential antiproliferative ... See more keywords
New Organoselenium (NSAIDs-Selenourea and Isoselenocyanate) Derivatives as Potential Antiproliferative Agents: Synthesis, Biological Evaluation and in Silico Calculations
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27144328
Abstract: In this study, we report on the synthesis of new organoselenium derivatives, including nonsteroidal anti-inflammatory drugs (NSAIDs) scaffolds and Se functionalities (isoselenocyanate and selenourea), which were evaluated against four types of cancer cell line: SW480… read more here.
Keywords: potential antiproliferative; antiproliferative agents; cancer cell; new organoselenium ... See more keywords